guest ::
| Home > Publications database > Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy. > print |
| Home > Publications database > Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy. > print |
| 001 | 125959 | ||
| 005 | 20240228143343.0 | ||
| 024 | 7 | _ | |a 10.1007/s00018-015-2087-8 |2 doi |
| 024 | 7 | _ | |a pmid:26611876 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4735260 |2 pmc |
| 024 | 7 | _ | |a 0014-4754 |2 ISSN |
| 024 | 7 | _ | |a 1420-682X |2 ISSN |
| 024 | 7 | _ | |a 1420-9071 |2 ISSN |
| 024 | 7 | _ | |a altmetric:4817190 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-02083 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Brady, Anne |0 P:(DE-He78)a8657988a6082d4d90605e15cd5d3302 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy. |
| 260 | _ | _ | |a Basel |c 2016 |b Birkhäuser |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521801170_16407 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Mitochondria are an essential source of ATP for cellular function, but when damaged, mitochondria generate a plethora of stress signals, which lead to cellular dysfunction and eventually programmed cell death. Thus, a major component of maintaining cellular homeostasis is the recognition and removal of dysfunctional mitochondria through autophagy-mediated degradation, i.e., mitophagy. Mitophagy further constitutes a developmental program, and undergoes a high degree of crosstalk with apoptosis. Reduced mitochondrial quality control is linked to disease pathogenesis, suggesting the importance of process elucidation as a clinical target. Recent work has revealed multiple mitophagy programs that operate independently or undergo crosstalk, and require modulated autophagy receptor activities at outer membranes of mitochondria. Here, we review these mitophagy programs, focusing on pathway mechanisms which recognize and target mitochondria for sequestration by autophagosomes, as well as mechanisms controlling pathway activities. Furthermore, we provide an introduction to the currently available methods for detecting mitophagy. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a BNIP3 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Membrane Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Microtubule-Associated Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Proto-Oncogene Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Ubiquitin |2 NLM Chemicals |
| 650 | _ | 7 | |a Ubiquitin-Protein Ligases |0 EC 2.3.2.27 |2 NLM Chemicals |
| 650 | _ | 7 | |a parkin protein |0 EC 2.3.2.27 |2 NLM Chemicals |
| 700 | 1 | _ | |a Brady, Nathan |0 P:(DE-He78)5bf984e94f0a31773a103cd293e01f92 |b 1 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1007/s00018-015-2087-8 |g Vol. 73, no. 4, p. 775 - 795 |0 PERI:(DE-600)1458497-9 |n 4 |p 775 - 795 |t Cellular and molecular life sciences |v 73 |y 2016 |x 1420-9071 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:125959 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-He78)a8657988a6082d4d90605e15cd5d3302 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 1 |6 P:(DE-He78)5bf984e94f0a31773a103cd293e01f92 |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |2 G:(DE-HGF)POF3-300 |v Functional and structural genomics |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2016 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1120 |2 StatID |b BIOSIS Reviews Reports And Meetings |
| 920 | 1 | _ | |0 I:(DE-He78)B190-20160331 |k B190 |l e:Bio Nachwuchsgruppe Lysosomale Systembiologie |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)B170-20160331 |k B170 |l Systembiologie von Zelltod-Mechanismen |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)B190-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B170-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|