% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{AfsharOromieh:125985,
      author       = {A. Afshar-Oromieh$^*$ and M. Wolf$^*$ and U. Haberkorn$^*$
                      and M. Kachelrieß$^*$ and R. Gnirs$^*$ and K. Kopka$^*$ and
                      H.-P. Schlemmer$^*$ and M. Freitag$^*$},
      title        = {{E}ffects of arm truncation on the appearance of the halo
                      artifact in (68){G}a-{PSMA}-11 ({HBED}-{CC}) {PET}/{MRI}.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {44},
      number       = {10},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DKFZ-2017-02100},
      pages        = {1636 - 1646},
      year         = {2017},
      abstract     = {PSMA ligand imaging with hybrid PET/MRI scanners could be
                      an integral part of the clinical routine in the future.
                      However, the first study about this novel method revealed a
                      severe photopenic artifact ('halo artifact') around the
                      urinary bladder causing significantly reduced tumor
                      visibility. The aim of this evaluation was to analyze the
                      role of arm truncation on the appearance of the halo
                      artifact in (68)Ga-PSMA-11 PET/MRI hypothesizing that this
                      influences the appearance.Twenty-seven consecutive patients
                      were subjected to (68)Ga-PSMA-11 PET/CT (1 h p.i.) followed
                      by PET/MRI (3 h p.i.). PET/MRI was first started with scans
                      of the abdomen to pelvis with arms positioned up above the
                      head. Immediately thereafter, additional scans from the
                      pelvis to abdomen were conducted with arms positioned down
                      beside the trunk. All investigations were first analyzed
                      separately and then compared with respect to tumor detection
                      and tumor uptake (SUV) as well as the presence and intensity
                      of the halo artifact. The Wilcoxon signed rank test was used
                      to determine statistical differences including Bonferroni
                      correction.The halo was significantly reduced if the arms
                      were elevated. Lesions inside the halo artifact (n = 16)
                      demonstrated significantly increased SUVmean (p = 0.0007)
                      and SUVmax (p = 0.0024) with arms positioned up. The halo
                      appearance and intensity was not dependent on the total
                      activity and activity concentration of the urinary
                      bladder.Positioning the arms down was shown to be
                      significantly associated with the appearance of the halo
                      artifact in PET/MRI. Positioning the arms up above the head
                      can significantly reduce the halo artifact, thereby
                      detecting more tumor lesions.},
      cin          = {E060 / E010 / E020 / E030},
      ddc          = {610},
      cid          = {I:(DE-He78)E060-20160331 / I:(DE-He78)E010-20160331 /
                      I:(DE-He78)E020-20160331 / I:(DE-He78)E030-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28508120},
      doi          = {10.1007/s00259-017-3718-0},
      url          = {https://inrepo02.dkfz.de/record/125985},
}