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@ARTICLE{An:126045,
      author       = {J. An and E. González-Avalos and A. Chawla and M. Jeong
                      and I. F. López-Moyado and W. Li and M. A. Goodell and L.
                      Chavez$^*$ and M. Ko and A. Rao},
      title        = {{A}cute loss of {TET} function results in aggressive
                      myeloid cancer in mice.},
      journal      = {Nature Communications},
      volume       = {6},
      issn         = {2041-1723},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2017-02160},
      pages        = {10071},
      year         = {2015},
      abstract     = {TET-family dioxygenases oxidize 5-methylcytosine (5mC) in
                      DNA, and exert tumour suppressor activity in many types of
                      cancers. Even in the absence of TET coding region mutations,
                      TET loss-of-function is strongly associated with cancer.
                      Here we show that acute elimination of TET function induces
                      the rapid development of an aggressive, fully-penetrant and
                      cell-autonomous myeloid leukaemia in mice, pointing to a
                      causative role for TET loss-of-function in this myeloid
                      malignancy. Phenotypic and transcriptional profiling shows
                      aberrant differentiation of haematopoietic stem/progenitor
                      cells, impaired erythroid and lymphoid differentiation and
                      strong skewing to the myeloid lineage, with only a mild
                      relation to changes in DNA modification. We also observe
                      progressive accumulation of phospho-H2AX and strong
                      impairment of DNA damage repair pathways, suggesting a key
                      role for TET proteins in maintaining genome integrity.},
      keywords     = {DNA-Binding Proteins (NLM Chemicals) / Histones (NLM
                      Chemicals) / Proto-Oncogene Proteins (NLM Chemicals) / RNA,
                      Messenger (NLM Chemicals) / Tet2 protein, mouse (NLM
                      Chemicals) / Tet3 protein, mouse (NLM Chemicals)},
      cin          = {B062},
      ddc          = {500},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26607761},
      pmc          = {pmc:PMC4674670},
      doi          = {10.1038/ncomms10071},
      url          = {https://inrepo02.dkfz.de/record/126045},
}