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| Home > Publications database > Acute loss of TET function results in aggressive myeloid cancer in mice. > print |
| 001 | 126045 | ||
| 005 | 20240228140805.0 | ||
| 024 | 7 | _ | |a 10.1038/ncomms10071 |2 doi |
| 024 | 7 | _ | |a pmid:26607761 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4674670 |2 pmc |
| 024 | 7 | _ | |a altmetric:4815598 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-02160 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a An, Jungeun |b 0 |
| 245 | _ | _ | |a Acute loss of TET function results in aggressive myeloid cancer in mice. |
| 260 | _ | _ | |a London |c 2015 |b Nature Publishing Group |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1508395871_7026 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a TET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and exert tumour suppressor activity in many types of cancers. Even in the absence of TET coding region mutations, TET loss-of-function is strongly associated with cancer. Here we show that acute elimination of TET function induces the rapid development of an aggressive, fully-penetrant and cell-autonomous myeloid leukaemia in mice, pointing to a causative role for TET loss-of-function in this myeloid malignancy. Phenotypic and transcriptional profiling shows aberrant differentiation of haematopoietic stem/progenitor cells, impaired erythroid and lymphoid differentiation and strong skewing to the myeloid lineage, with only a mild relation to changes in DNA modification. We also observe progressive accumulation of phospho-H2AX and strong impairment of DNA damage repair pathways, suggesting a key role for TET proteins in maintaining genome integrity. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a DNA-Binding Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Histones |2 NLM Chemicals |
| 650 | _ | 7 | |a Proto-Oncogene Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a RNA, Messenger |2 NLM Chemicals |
| 650 | _ | 7 | |a Tet2 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Tet3 protein, mouse |2 NLM Chemicals |
| 700 | 1 | _ | |a González-Avalos, Edahí |b 1 |
| 700 | 1 | _ | |a Chawla, Ashu |b 2 |
| 700 | 1 | _ | |a Jeong, Mira |b 3 |
| 700 | 1 | _ | |a López-Moyado, Isaac F |b 4 |
| 700 | 1 | _ | |a Li, Wei |b 5 |
| 700 | 1 | _ | |a Goodell, Margaret A |b 6 |
| 700 | 1 | _ | |a Chavez, Lukas |0 P:(DE-He78)082dd3179733e3e716a58eb90f418a78 |b 7 |u dkfz |
| 700 | 1 | _ | |a Ko, Myunggon |b 8 |
| 700 | 1 | _ | |a Rao, Anjana |b 9 |
| 773 | _ | _ | |a 10.1038/ncomms10071 |g Vol. 6, p. 10071 - |0 PERI:(DE-600)2553671-0 |p 10071 |t Nature Communications |v 6 |y 2015 |x 2041-1723 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:126045 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 7 |6 P:(DE-He78)082dd3179733e3e716a58eb90f418a78 |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |2 G:(DE-HGF)POF3-300 |v Functional and structural genomics |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2015 |
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| 915 | _ | _ | |a Creative Commons Attribution CC BY (No Version) |0 LIC:(DE-HGF)CCBYNV |2 V:(DE-HGF) |b DOAJ |
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| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |
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| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |
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| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l Pädiatrische Neuroonkologie |x 0 |
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