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000126065 0247_ $$2doi$$a10.1038/ncomms5005
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000126065 1001_ $$aJeibmann, Astrid$$b0
000126065 245__ $$aIdentification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster.
000126065 260__ $$aLondon$$bNature Publishing Group$$c2014
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000126065 520__ $$aAtypical teratoid/rhabdoid tumours (AT/RT) are malignant brain tumours. Unlike most other human brain tumours, AT/RT are characterized by inactivation of one single gene, SMARCB1. SMARCB1 is a member of the evolutionarily conserved SWI/SNF chromatin remodelling complex, which has an important role in the control of cell differentiation and proliferation. Little is known, however, about the pathways involved in the oncogenic effects of SMARCB1 inactivation, which might also represent targets for treatment. Here we report a comprehensive genetic screen in the fruit fly that revealed several genes not yet associated with loss of snr1, the Drosophila homologue of SMARCB1. We confirm the functional role of identified genes (including merlin, kibra and expanded, known to regulate hippo signalling pathway activity) in human rhabdoid tumour cell lines and AT/RT tumour samples. These results demonstrate that fly models can be employed for the identification of clinically relevant pathways in human cancer.
000126065 536__ $$0G:(DE-HGF)POF3-312$$a312 - Functional and structural genomics (POF3-312)$$cPOF3-312$$fPOF III$$x0
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000126065 650_7 $$2NLM Chemicals$$aChromosomal Proteins, Non-Histone
000126065 650_7 $$2NLM Chemicals$$aDNA-Binding Proteins
000126065 650_7 $$2NLM Chemicals$$aDrosophila Proteins
000126065 650_7 $$2NLM Chemicals$$aIntracellular Signaling Peptides and Proteins
000126065 650_7 $$2NLM Chemicals$$aMembrane Proteins
000126065 650_7 $$2NLM Chemicals$$aNeurofibromin 2
000126065 650_7 $$2NLM Chemicals$$aSMARCB1 Protein
000126065 650_7 $$2NLM Chemicals$$aSMARCB1 protein, human
000126065 650_7 $$2NLM Chemicals$$aSnr1 protein, Drosophila
000126065 650_7 $$2NLM Chemicals$$aTranscription Factors
000126065 650_7 $$2NLM Chemicals$$aTumor Suppressor Proteins
000126065 650_7 $$2NLM Chemicals$$aexpanded protein, Drosophila
000126065 650_7 $$2NLM Chemicals$$akibra protein, Drosophila
000126065 650_7 $$2NLM Chemicals$$amerlin, Drosophila
000126065 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aProtein-Serine-Threonine Kinases
000126065 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$ahpo protein, Drosophila
000126065 7001_ $$aEikmeier, Kristin$$b1
000126065 7001_ $$aLinge, Anna$$b2
000126065 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b3$$udkfz
000126065 7001_ $$aKoos, Björn$$b4
000126065 7001_ $$aSchulz, Jacqueline$$b5
000126065 7001_ $$aAlbrecht, Stefanie$$b6
000126065 7001_ $$aBartelheim, Kerstin$$b7
000126065 7001_ $$aFrühwald, Michael C$$b8
000126065 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b9$$udkfz
000126065 7001_ $$aPaulus, Werner$$b10
000126065 7001_ $$aHasselblatt, Martin$$b11
000126065 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/ncomms5005$$gVol. 5$$p4005$$tNature Communications$$v5$$x2041-1723$$y2014
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