%0 Journal Article
%A Butzlaff, Malte
%A Hannan, Shabab B
%A Karsten, Peter
%A Lenz, Sarah
%A Ng, Josephine
%A Voßfeldt, Hannes
%A Prüßing, Katja
%A Pflanz, Ralf
%A Schulz, Jörg B
%A Rasse, Tobias
%A Voigt, Aaron
%T Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity.
%J Human molecular genetics
%V 24
%N 13
%@ 1460-2083
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2017-02334
%P 3623 - 3637
%D 2015
%X The gene mapt codes for the microtubule-associated protein Tau. The R406W amino acid substitution in Tau is associated with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) characterized by Tau-positive filamentous inclusions. These filamentous Tau inclusions are present in a group of neurodegenerative diseases known as tauopathies, including Alzheimer's disease (AD). To gain more insights into the pathomechanism of tauopathies, we performed an RNAi-based large-scale screen in Drosophila melanogaster to identify genetic modifiers of Tau[R406W]-induced toxicity. A collection of RNAi lines, putatively silencing more than 7000 genes, was screened for the ability to modify Tau[R406W]-induced toxicity in vivo. This collection covered more than 50
%K Drosophila Proteins (NLM Chemicals)
%K Microtubule-Associated Proteins (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%K tau protein, Drosophila (NLM Chemicals)
%K Dyneins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25794683
%R 10.1093/hmg/ddv107
%U https://inrepo02.dkfz.de/record/126219