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@ARTICLE{Codutti:126274,
      author       = {L. Codutti and K. Leppek$^*$ and J. Zálešák and V.
                      Windeisen and P. Masiewicz and G. Stoecklin$^*$ and T.
                      Carlomagno},
      title        = {{A} {D}istinct, {S}equence-{I}nduced {C}onformation {I}s
                      {R}equired for {R}ecognition of the {C}onstitutive {D}ecay
                      {E}lement {RNA} by {R}oquin.},
      journal      = {Structure},
      volume       = {23},
      number       = {8},
      issn         = {0969-2126},
      address      = {London [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2017-02389},
      pages        = {1437 - 1447},
      year         = {2015},
      abstract     = {The constitutive decay element (CDE) of tumor necrosis
                      factor α (TNF-α) mRNA (Tnf) represents the prototype of a
                      class of RNA motifs that mediate rapid degradation of mRNAs
                      encoding regulators of the immune response and development.
                      CDE-type RNAs are hairpin structures featuring a
                      tri-nucleotide loop. The protein Roquin recognizes CDE-type
                      stem loops and recruits the Ccr4-Caf1-Not deadenylase
                      complex to the mRNA, thereby inducing its decay. Stem
                      recognition does not involve nucleotide bases; however,
                      there is a strong stem sequence requirement for functional
                      CDEs. Here, we present the solution structures of the
                      natural Tnf CDE and of a CDE mutant with impaired Roquin
                      binding. We find that the two CDEs adopt unique and distinct
                      structures in both the loop and the stem, which explains the
                      ability of Roquin to recognize stem loops in a
                      sequence-specific manner. Our findings result in a relaxed
                      consensus motif for prediction of new CDE stem loops.},
      keywords     = {RC3H1 protein, human (NLM Chemicals) / RNA, Messenger (NLM
                      Chemicals) / RNA-Binding Proteins (NLM Chemicals) /
                      Recombinant Proteins (NLM Chemicals) / Ubiquitin-Protein
                      Ligases (NLM Chemicals)},
      cin          = {A200},
      ddc          = {570},
      cid          = {I:(DE-He78)A200-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26165594},
      doi          = {10.1016/j.str.2015.06.001},
      url          = {https://inrepo02.dkfz.de/record/126274},
}