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@ARTICLE{Ramaswamy:126391,
      author       = {V. Ramaswamy and M. Remke and D. Shih and X. Wang and P. A.
                      Northcott$^*$ and C. C. Faria and C. Raybaud and U. Tabori
                      and C. Hawkins and J. Rutka and M. D. Taylor and E. Bouffet},
      title        = {{D}uration of the pre-diagnostic interval in
                      medulloblastoma is subgroup dependent.},
      journal      = {Pediatric blood $\&$ cancer},
      volume       = {61},
      number       = {7},
      issn         = {1545-5009},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DKFZ-2017-02420},
      pages        = {1190 - 1194},
      year         = {2014},
      abstract     = {Children presenting with medulloblastoma have a wide range
                      of initial presenting symptoms. However, the influence of
                      underlying tumor biology on the initial presentation of
                      medulloblastoma is currently unknown. In light of the recent
                      discovery of distinct medulloblastoma subgroups, we sought
                      to define the initial presentation of childhood
                      medulloblastoma in a subgroup specific manner.We assembled a
                      cohort of 126 medulloblastoma cases at the Hospital for Sick
                      Children between 1994 and 2012 and determined subgroup
                      affiliation using nanoString. Clinical details pertaining to
                      the initial presentation were determined through a
                      retrospective chart review.The median pre-diagnostic
                      interval across all medulloblastoma cases was 4 weeks (IQR:
                      4-12 weeks). Strikingly, when the pre-diagnostic interval
                      was then determined in a subgroup specific manner, cases
                      with WNT and Group 4 tumors showed significantly longer
                      median pre-diagnostic intervals of 8 weeks compared to 2
                      weeks for SHH and 4 weeks for Group 3 (P = 0.0001). Younger
                      age was significantly associated with a prolonged
                      pre-diagnostic interval (P = 0.02 for all). When stratifying
                      by subgroup the association with age was only significant in
                      Group 4 (P = 0.04 for Group 4). Improved survival was
                      significantly associated with a longer pre-diagnostic
                      interval (P = 0.02), however is no longer significant when
                      controlling for subgroup (P = 0.07).The duration of the
                      pre-diagnostic interval in childhood medulloblastoma is
                      highly subgroup dependent, further highlighting the clinical
                      heterogeneity and biological relevance of the four principle
                      subgroups of medulloblastoma.},
      cin          = {B062},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24616042},
      doi          = {10.1002/pbc.25002},
      url          = {https://inrepo02.dkfz.de/record/126391},
}