TY  - JOUR
AU  - Dietrich, Sascha
AU  - Radujkovic, Aleksandar
AU  - Stölzel, Friedrich
AU  - Falk, Christine S
AU  - Benner, Axel
AU  - Schaich, Markus
AU  - Bornhäuser, Martin
AU  - Ehninger, Gerhard
AU  - Krämer, Alwin
AU  - Hegenbart, Ute
AU  - Ho, Anthony D
AU  - Dreger, Peter
AU  - Luft, Thomas
TI  - Pretransplant metabolic distress predicts relapse of acute myeloid leukemia after allogeneic stem cell transplantation.
JO  - Transplantation
VL  - 99
IS  - 5
SN  - 0041-1337
CY  - Hagerstown, Md.
PB  - Lippincott Williams & Wilkins
M1  - DKFZ-2017-02464
SP  - 1065 - 1071
PY  - 2015
AB  - The impact of nutritional status on outcome of allogeneic stem cell transplantation (alloSCT) is controversial. This study investigates the influence of pretransplant weight loss and serologic indicators of nutritional homeostasis on relapse and death of acute myeloid leukemia (AML) after alloSCT.Pretransplant weight loss along with serum levels of total serum protein (TSP), albumin, C-reactive protein, and leptin were collected retrospectively in a training cohort (n = 149) and correlated with clinical outcome. Metabolic risk groups were defined and tested in an independent validation cohort (n = 167).We identified pretransplant weight loss and TSP as strong independent predictors of relapse and death. Patients in the metabolic high-risk group (low TSP and weight loss) had an increased risk for relapse (P = 0.0002) and death (P = 0.002), but a similar risk for acute graft-versus-host disease. Weight loss coincided with reduced pretransplant serum leptin levels. The adverse influence of weight loss and high metabolic risk on relapse and overall survival could be confirmed in the validation cohort and similarly in patients with less than or more than 5
KW  - Blood Proteins (NLM Chemicals)
KW  - Leptin (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25340610
DO  - DOI:10.1097/TP.0000000000000471
UR  - https://inrepo02.dkfz.de/record/126435
ER  -