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000126521 1001_ $$aFontebasso, Adam M$$b0
000126521 245__ $$aNon-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age.
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000126521 520__ $$aPilocytic astrocytoma (PA) is the most common brain tumor in children but is rare in adults, and hence poorly studied in this age group. We investigated 222 PA and report increased aneuploidy in older patients. Aneuploid genomes were identified in 45% of adult compared with 17% of pediatric PA. Gains were non-random, favoring chromosomes 5, 7, 6 and 11 in order of frequency, and preferentially affecting non-cerebellar PA and tumors with BRAF V600E mutations and not with KIAA1549-BRAF fusions or FGFR1 mutations. Aneuploid PA differentially expressed genes involved in CNS development, the unfolded protein response, and regulators of genomic stability and the cell cycle (MDM2, PLK2),whose correlated programs were overexpressed specifically in aneuploid PA compared to other glial tumors. Thus, convergence of pathways affecting the cell cycle and genomic stability may favor aneuploidy in PA, possibly representing an additional molecular driver in older patients with this brain tumor.
000126521 536__ $$0G:(DE-HGF)POF3-312$$a312 - Functional and structural genomics (POF3-312)$$cPOF3-312$$fPOF III$$x0
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000126521 650_7 $$2NLM Chemicals$$aBiomarkers, Tumor
000126521 650_7 $$2NLM Chemicals$$aRNA, Messenger
000126521 650_7 $$0EC 2.3.2.27$$2NLM Chemicals$$aMDM2 protein, human
000126521 650_7 $$0EC 2.3.2.27$$2NLM Chemicals$$aProto-Oncogene Proteins c-mdm2
000126521 650_7 $$0EC 2.7.10.1$$2NLM Chemicals$$aFGFR1 protein, human
000126521 650_7 $$0EC 2.7.10.1$$2NLM Chemicals$$aReceptor, Fibroblast Growth Factor, Type 1
000126521 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aBRAF protein, human
000126521 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aProto-Oncogene Proteins B-raf
000126521 7001_ $$aShirinian, Margret$$b1
000126521 7001_ $$aKhuong-Quang, Dong-Anh$$b2
000126521 7001_ $$aBechet, Denise$$b3
000126521 7001_ $$aGayden, Tenzin$$b4
000126521 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b5$$udkfz
000126521 7001_ $$aDe Jay, Nicolas$$b6
000126521 7001_ $$aJacob, Karine$$b7
000126521 7001_ $$aGerges, Noha$$b8
000126521 7001_ $$0P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0$$aHutter, Barbara$$b9$$udkfz
000126521 7001_ $$0P:(DE-HGF)0$$aŞeker-Cin, Huriye$$b10
000126521 7001_ $$0P:(DE-He78)046fd145f1008f83f6236580727bbc0f$$aWitt, Hendrik$$b11$$udkfz
000126521 7001_ $$aMontpetit, Alexandre$$b12
000126521 7001_ $$aBrunet, Sébastien$$b13
000126521 7001_ $$aLepage, Pierre$$b14
000126521 7001_ $$aBourret, Geneviève$$b15
000126521 7001_ $$aKlekner, Almos$$b16
000126521 7001_ $$aBognár, László$$b17
000126521 7001_ $$aHauser, Peter$$b18
000126521 7001_ $$aGarami, Miklós$$b19
000126521 7001_ $$aFarmer, Jean-Pierre$$b20
000126521 7001_ $$aMontes, Jose-Luis$$b21
000126521 7001_ $$aAtkinson, Jeffrey$$b22
000126521 7001_ $$aLambert, Sally$$b23
000126521 7001_ $$aKwan, Tony$$b24
000126521 7001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b25$$udkfz
000126521 7001_ $$aTabori, Uri$$b26
000126521 7001_ $$aCollins, V Peter$$b27
000126521 7001_ $$aAlbrecht, Steffen$$b28
000126521 7001_ $$aFaury, Damien$$b29
000126521 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b30$$udkfz
000126521 7001_ $$aPaulus, Werner$$b31
000126521 7001_ $$aHasselblatt, Martin$$b32
000126521 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b33$$udkfz
000126521 7001_ $$aJabado, Nada$$b34
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