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@ARTICLE{Fontebasso:126521,
      author       = {A. M. Fontebasso and M. Shirinian and D.-A. Khuong-Quang
                      and D. Bechet and T. Gayden and M. Kool$^*$ and N. De Jay
                      and K. Jacob and N. Gerges and B. Hutter$^*$ and H.
                      Şeker-Cin$^*$ and H. Witt$^*$ and A. Montpetit and S.
                      Brunet and P. Lepage and G. Bourret and A. Klekner and L.
                      Bognár and P. Hauser and M. Garami and J.-P. Farmer and
                      J.-L. Montes and J. Atkinson and S. Lambert and T. Kwan and
                      A. Korshunov$^*$ and U. Tabori and V. P. Collins and S.
                      Albrecht and D. Faury and S. Pfister$^*$ and W. Paulus and
                      M. Hasselblatt and D. Jones$^*$ and N. Jabado},
      title        = {{N}on-random aneuploidy specifies subgroups of pilocytic
                      astrocytoma and correlates with older age.},
      journal      = {OncoTarget},
      volume       = {6},
      number       = {31},
      issn         = {1949-2553},
      address      = {[S.l.]},
      publisher    = {Impact Journals LLC},
      reportid     = {DKFZ-2017-02549},
      pages        = {31844 - 31856},
      year         = {2015},
      abstract     = {Pilocytic astrocytoma (PA) is the most common brain tumor
                      in children but is rare in adults, and hence poorly studied
                      in this age group. We investigated 222 PA and report
                      increased aneuploidy in older patients. Aneuploid genomes
                      were identified in $45\%$ of adult compared with $17\%$ of
                      pediatric PA. Gains were non-random, favoring chromosomes 5,
                      7, 6 and 11 in order of frequency, and preferentially
                      affecting non-cerebellar PA and tumors with BRAF V600E
                      mutations and not with KIAA1549-BRAF fusions or FGFR1
                      mutations. Aneuploid PA differentially expressed genes
                      involved in CNS development, the unfolded protein response,
                      and regulators of genomic stability and the cell cycle
                      (MDM2, PLK2),whose correlated programs were overexpressed
                      specifically in aneuploid PA compared to other glial tumors.
                      Thus, convergence of pathways affecting the cell cycle and
                      genomic stability may favor aneuploidy in PA, possibly
                      representing an additional molecular driver in older
                      patients with this brain tumor.},
      keywords     = {Biomarkers, Tumor (NLM Chemicals) / RNA, Messenger (NLM
                      Chemicals) / MDM2 protein, human (NLM Chemicals) /
                      Proto-Oncogene Proteins c-mdm2 (NLM Chemicals) / FGFR1
                      protein, human (NLM Chemicals) / Receptor, Fibroblast Growth
                      Factor, Type 1 (NLM Chemicals) / BRAF protein, human (NLM
                      Chemicals) / Proto-Oncogene Proteins B-raf (NLM Chemicals)},
      cin          = {B062 / G200 / G380},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)G200-20160331 /
                      I:(DE-He78)G380-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26378811},
      pmc          = {pmc:PMC4741644},
      doi          = {10.18632/oncotarget.5571},
      url          = {https://inrepo02.dkfz.de/record/126521},
}