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000126526 0247_ $$2doi$$a10.1007/s00441-014-2053-z
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000126526 0247_ $$2ISSN$$a0302-766X
000126526 0247_ $$2ISSN$$a0340-0336
000126526 0247_ $$2ISSN$$a0373-031X
000126526 0247_ $$2ISSN$$a1432-0878
000126526 037__ $$aDKFZ-2017-02554
000126526 041__ $$aeng
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000126526 1001_ $$0P:(DE-He78)7603e07539216b364cdb015f67872c66$$aFranke, Werner$$b0$$eFirst author$$udkfz
000126526 245__ $$aStriatins as plaque molecules of zonulae adhaerentes in simple epithelia, of tessellate junctions in stratified epithelia, of cardiac composite junctions and of various size classes of lateral adherens junctions in cultures of epithelia- and carcinoma-derived cells.
000126526 260__ $$aBerlin$$bSpringer$$c2015
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000126526 520__ $$aProteins of the striatin family (striatins 1-4; sizes ranging from 90 to 110 kDa on SDS-polyacrylamide gel electrophoresis) are highly homologous in their amino acid sequences but can differ in their cell-type-specific gene expression patterns and biological functions. In various cell types, we have found one, two or three polypeptides of this evolutionarily old and nearly ubiquitous family of proteins known to serve as scaffold proteins for diverse protein complexes. Light and electron microscopic immunolocalization methods have revealed striatins in mammalian cell-cell adherens junctions (AJs). In simple epithelia, we have localized striatins as constitutive components of the plaques of the subapical zonulae adhaerentes of cells, including intestinal, glandular, ductal and urothelial cells and hepatocytes. Striatins colocalize with E-cadherin or E-N-cadherin heterodimers and with the plaque proteins α- and β-catenin, p120 and p0071. In some epithelia and carcinomas and in cultured cells derived therefrom, striatins are also seen in lateral AJs. In stratified epithelia and in corresponding squamous cell carcinomas, striatins can be found in plaques of some forms of tessellate junctions. Moreover, striatins are major plaque proteins of composite junctions (CJs; areae compositae) in the intercalated disks connecting cardiomyocytes, colocalizing with other CJ molecules, including plectin and ankyrin-G. We discuss the 'multimodulator' scaffold roles of striatins in the initiation and regulation of the formation of various complex particles and structures. We propose that striatins are included in the diagnostic candidate list of proteins that, in the CJs of human hearts, can occur in mutated forms in the pathogeneses of hereditary cardiomyopathies, as seen in some types of genetically determined heart damage in boxer dogs.
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000126526 650_7 $$2NLM Chemicals$$aAntibodies
000126526 650_7 $$2NLM Chemicals$$aCalmodulin-Binding Proteins
000126526 650_7 $$2NLM Chemicals$$aMembrane Proteins
000126526 650_7 $$2NLM Chemicals$$aNerve Tissue Proteins
000126526 650_7 $$2NLM Chemicals$$aSTRN protein, human
000126526 7001_ $$0P:(DE-HGF)0$$aRickelt, Steffen$$b1
000126526 7001_ $$0P:(DE-He78)7c58721b8a5cf92cb78cb3fad538ce3c$$aZimbelmann, Ralf$$b2$$udkfz
000126526 7001_ $$0P:(DE-He78)0f83789bc03d3966a9a786684c9b15e5$$aDörflinger, Yvette$$b3$$udkfz
000126526 7001_ $$0P:(DE-HGF)0$$aKuhn, Caecilia$$b4
000126526 7001_ $$aFrey, Norbert$$b5
000126526 7001_ $$0P:(DE-He78)c63edb4f71da4cb5b1316391da0f209c$$aHeid, Hans$$b6$$udkfz
000126526 7001_ $$aRosin-Arbesfeld, Rina$$b7
000126526 773__ $$0PERI:(DE-600)1458496-7$$a10.1007/s00441-014-2053-z$$gVol. 359, no. 3, p. 779 - 797$$n3$$p779 - 797$$tCell & tissue research$$v359$$x1432-0878$$y2015
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000126526 9141_ $$y2015
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