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| Home > Publications database > MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin. > print |
| Home > Publications database > MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin. > print |
| 001 | 126558 | ||
| 005 | 20240228140832.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ccell.2015.10.005 |2 doi |
| 024 | 7 | _ | |a pmid:26626085 |2 pmid |
| 024 | 7 | _ | |a 1535-6108 |2 ISSN |
| 024 | 7 | _ | |a 1878-3686 |2 ISSN |
| 024 | 7 | _ | |a altmetric:4806726 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-02586 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Gallo, Marco |b 0 |
| 245 | _ | _ | |a MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2015 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1508414329_7026 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Mutations in the histone 3 variant H3.3 have been identified in one-third of pediatric glioblastomas (GBMs), but not in adult tumors. Here we show that H3.3 is a dynamic determinant of functional properties in adult GBM. H3.3 is repressed by mixed lineage leukemia 5 (MLL5) in self-renewing GBM cells. MLL5 is a global epigenetic repressor that orchestrates reorganization of chromatin structure by punctuating chromosomes with foci of compacted chromatin, favoring tumorigenic and self-renewing properties. Conversely, H3.3 antagonizes self-renewal and promotes differentiation. We exploited these epigenetic states to rationally identify two small molecules that effectively curb cancer stem cell properties in a preclinical model. Our work uncovers a role for MLL5 and H3.3 in maintaining self-renewal hierarchies in adult GBM. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Antineoplastic Agents |2 NLM Chemicals |
| 650 | _ | 7 | |a DNA-Binding Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Histones |2 NLM Chemicals |
| 650 | _ | 7 | |a MLL5 protein, human |2 NLM Chemicals |
| 700 | 1 | _ | |a Coutinho, Fiona J |b 1 |
| 700 | 1 | _ | |a Vanner, Robert J |b 2 |
| 700 | 1 | _ | |a Gayden, Tenzin |b 3 |
| 700 | 1 | _ | |a Mack, Stephen C |b 4 |
| 700 | 1 | _ | |a Murison, Alex |b 5 |
| 700 | 1 | _ | |a Remke, Marc |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Li, Ren |b 7 |
| 700 | 1 | _ | |a Takayama, Naoya |b 8 |
| 700 | 1 | _ | |a Desai, Kinjal |b 9 |
| 700 | 1 | _ | |a Lee, Lilian |b 10 |
| 700 | 1 | _ | |a Lan, Xiaoyang |b 11 |
| 700 | 1 | _ | |a Park, Nicole I |b 12 |
| 700 | 1 | _ | |a Barsyte-Lovejoy, Dalia |b 13 |
| 700 | 1 | _ | |a Smil, David |b 14 |
| 700 | 1 | _ | |a Sturm, Dominik |0 P:(DE-He78)a46a5b2a871859c8e2d63d2f8c666807 |b 15 |u dkfz |
| 700 | 1 | _ | |a Kushida, Michelle M |b 16 |
| 700 | 1 | _ | |a Head, Renee |b 17 |
| 700 | 1 | _ | |a Cusimano, Michael D |b 18 |
| 700 | 1 | _ | |a Bernstein, Mark |b 19 |
| 700 | 1 | _ | |a Clarke, Ian D |b 20 |
| 700 | 1 | _ | |a Dick, John E |b 21 |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 22 |u dkfz |
| 700 | 1 | _ | |a Rich, Jeremy N |b 23 |
| 700 | 1 | _ | |a Arrowsmith, Cheryl H |b 24 |
| 700 | 1 | _ | |a Taylor, Michael D |b 25 |
| 700 | 1 | _ | |a Jabado, Nada |b 26 |
| 700 | 1 | _ | |a Bazett-Jones, David P |b 27 |
| 700 | 1 | _ | |a Lupien, Mathieu |b 28 |
| 700 | 1 | _ | |a Dirks, Peter B |b 29 |
| 773 | _ | _ | |a 10.1016/j.ccell.2015.10.005 |g Vol. 28, no. 6, p. 715 - 729 |0 PERI:(DE-600)2074034-7 |n 6 |p 715 - 729 |t Cancer cell |v 28 |y 2015 |x 1535-6108 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:126558 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 15 |6 P:(DE-He78)a46a5b2a871859c8e2d63d2f8c666807 |
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