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000126585 1001_ $$aGiachino, Claudio$$b0
000126585 245__ $$aA Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes.
000126585 260__ $$aCambridge, Mass.$$bCell Press$$c2015
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000126585 520__ $$aIn the brain, Notch signaling maintains normal neural stem cells, but also brain cancer stem cells, indicating an oncogenic role. Here, we identify an unexpected tumor suppressor function for Notch in forebrain tumor subtypes. Genetic inactivation of RBP-Jκ, a key Notch mediator, or Notch1 and Notch2 receptors accelerates PDGF-driven glioma growth in mice. Conversely, genetic activation of the Notch pathway reduces glioma growth and increases survival. In humans, high Notch activity strongly correlates with distinct glioma subtypes, increased patient survival, and lower tumor grade. Additionally, simultaneous inactivation of RBP-Jκ and p53 induces primitive neuroectodermal-like tumors in mice. Hence, Notch signaling cooperates with p53 to restrict cell proliferation and tumor growth in mouse models of human brain tumors.
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000126585 650_7 $$2NLM Chemicals$$aBasic Helix-Loop-Helix Transcription Factors
000126585 650_7 $$2NLM Chemicals$$aHes5 protein, mouse
000126585 650_7 $$2NLM Chemicals$$aImmunoglobulin J Recombination Signal Sequence-Binding Protein
000126585 650_7 $$2NLM Chemicals$$aNotch1 protein, mouse
000126585 650_7 $$2NLM Chemicals$$aNotch2 protein, mouse
000126585 650_7 $$2NLM Chemicals$$aPlatelet-Derived Growth Factor
000126585 650_7 $$2NLM Chemicals$$aProto-Oncogene Proteins c-sis
000126585 650_7 $$2NLM Chemicals$$aRbpj protein, mouse
000126585 650_7 $$2NLM Chemicals$$aReceptor, Notch1
000126585 650_7 $$2NLM Chemicals$$aReceptor, Notch2
000126585 650_7 $$2NLM Chemicals$$aReceptors, Notch
000126585 650_7 $$2NLM Chemicals$$aRecombinant Proteins
000126585 650_7 $$2NLM Chemicals$$aRepressor Proteins
000126585 650_7 $$2NLM Chemicals$$aTumor Suppressor Protein p53
000126585 650_7 $$2NLM Chemicals$$aTumor Suppressor Proteins
000126585 650_7 $$2NLM Chemicals$$aplatelet-derived growth factor A
000126585 7001_ $$aBoulay, Jean-Louis$$b1
000126585 7001_ $$aIvanek, Robert$$b2
000126585 7001_ $$aAlvarado, Alvaro$$b3
000126585 7001_ $$aTostado, Cristobal$$b4
000126585 7001_ $$aLugert, Sebastian$$b5
000126585 7001_ $$aTchorz, Jan$$b6
000126585 7001_ $$aCoban, Mustafa$$b7
000126585 7001_ $$aMariani, Luigi$$b8
000126585 7001_ $$aBettler, Bernhard$$b9
000126585 7001_ $$aLathia, Justin$$b10
000126585 7001_ $$aFrank, Stephan$$b11
000126585 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b12$$udkfz
000126585 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b13$$udkfz
000126585 7001_ $$aTaylor, Verdon$$b14
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