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| 001 | 126585 | ||
| 005 | 20240228140834.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ccell.2015.10.008 |2 doi |
| 024 | 7 | _ | |a pmid:26669487 |2 pmid |
| 024 | 7 | _ | |a 1535-6108 |2 ISSN |
| 024 | 7 | _ | |a 1878-3686 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2017-02613 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Giachino, Claudio |b 0 |
| 245 | _ | _ | |a A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2015 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1508414604_6998 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a In the brain, Notch signaling maintains normal neural stem cells, but also brain cancer stem cells, indicating an oncogenic role. Here, we identify an unexpected tumor suppressor function for Notch in forebrain tumor subtypes. Genetic inactivation of RBP-Jκ, a key Notch mediator, or Notch1 and Notch2 receptors accelerates PDGF-driven glioma growth in mice. Conversely, genetic activation of the Notch pathway reduces glioma growth and increases survival. In humans, high Notch activity strongly correlates with distinct glioma subtypes, increased patient survival, and lower tumor grade. Additionally, simultaneous inactivation of RBP-Jκ and p53 induces primitive neuroectodermal-like tumors in mice. Hence, Notch signaling cooperates with p53 to restrict cell proliferation and tumor growth in mouse models of human brain tumors. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Basic Helix-Loop-Helix Transcription Factors |2 NLM Chemicals |
| 650 | _ | 7 | |a Hes5 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Immunoglobulin J Recombination Signal Sequence-Binding Protein |2 NLM Chemicals |
| 650 | _ | 7 | |a Notch1 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Notch2 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Platelet-Derived Growth Factor |2 NLM Chemicals |
| 650 | _ | 7 | |a Proto-Oncogene Proteins c-sis |2 NLM Chemicals |
| 650 | _ | 7 | |a Rbpj protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptor, Notch1 |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptor, Notch2 |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, Notch |2 NLM Chemicals |
| 650 | _ | 7 | |a Recombinant Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Repressor Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Tumor Suppressor Protein p53 |2 NLM Chemicals |
| 650 | _ | 7 | |a Tumor Suppressor Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a platelet-derived growth factor A |2 NLM Chemicals |
| 700 | 1 | _ | |a Boulay, Jean-Louis |b 1 |
| 700 | 1 | _ | |a Ivanek, Robert |b 2 |
| 700 | 1 | _ | |a Alvarado, Alvaro |b 3 |
| 700 | 1 | _ | |a Tostado, Cristobal |b 4 |
| 700 | 1 | _ | |a Lugert, Sebastian |b 5 |
| 700 | 1 | _ | |a Tchorz, Jan |b 6 |
| 700 | 1 | _ | |a Coban, Mustafa |b 7 |
| 700 | 1 | _ | |a Mariani, Luigi |b 8 |
| 700 | 1 | _ | |a Bettler, Bernhard |b 9 |
| 700 | 1 | _ | |a Lathia, Justin |b 10 |
| 700 | 1 | _ | |a Frank, Stephan |b 11 |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 12 |u dkfz |
| 700 | 1 | _ | |a Kool, Marcel |0 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |b 13 |u dkfz |
| 700 | 1 | _ | |a Taylor, Verdon |b 14 |
| 773 | _ | _ | |a 10.1016/j.ccell.2015.10.008 |g Vol. 28, no. 6, p. 730 - 742 |0 PERI:(DE-600)2074034-7 |n 6 |p 730 - 742 |t Cancer cell |v 28 |y 2015 |x 1535-6108 |
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