%0 Journal Article
%A Goeppert, Benjamin
%A Frauenschuh, Lena
%A Zucknick, Manuela
%A Roessler, Stephanie
%A Mehrabi, Arianeb
%A Hafezi, Mohammadreza
%A Stenzinger, Albrecht
%A Warth, Arne
%A Pathil, Anita
%A Renner, Marcus
%A Schirmacher, Peter
%A Weichert, Wilko
%T Major histocompatibility complex class I expression impacts on patient survival and type and density of immune cells in biliary tract cancer.
%J British journal of cancer
%V 113
%N 9
%@ 1532-1827
%C Edinburgh
%I Nature Publ. Group
%M DKFZ-2017-02628
%P 1343 - 1349
%D 2015
%X Biliary tract cancers (BTC) are rare malignant tumours with a poor prognosis. Previously, we have presented a detailed characterisation of the inflammatory infiltrate in BTC. Here, we analysed the impact of the expression of major histocompatibility complex class I (MHC I) on patient survival and the quantity, as well as the quality of tumour-infiltrating immune cell types in BTC.MHC I expression was assessed semi-quantitatively in 334 BTC, including extrahepatic (n=129) and intrahepatic cholangiocarcinomas (n=146), as well as adenocarcinomas of the gallbladder (n=59). In addition, 71 high-grade biliary intraepithelial lesions (BilIN 3) were included. Results were correlated with data on antitumour inflammation and investigated with respect to their association with clinicopathological variables and patient survival.BTC showed a wide spectrum of different MHC I expression patterns ranging from complete negativity in some tumours to strong homogenous expression in others. In BilIN 3, significantly higher MHC I expression levels were seen compared to invasive tumours (P=0.004). Patients with strong tumoural MHC I expression had a significantly higher overall survival probability (median survival benefit: 8 months; P=0.006). MHC I expression strongly correlated with the number of tumour-infiltrating T-lymphocytes (CD4(+) and CD8(+)) and macrophages.Differences of MHC I expression predict patient outcome and show correlations with specific components of the inflammatory infiltrate in BTC. These findings contribute to a better understanding of immune response and immune escape phenomena in cholangiocarcinogenesis.
%K Histocompatibility Antigens Class I (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26461054
%2 pmc:PMC4815783
%R 10.1038/bjc.2015.337
%U https://inrepo02.dkfz.de/record/126600