TY  - JOUR
AU  - Goeppert, Benjamin
AU  - Frauenschuh, Lena
AU  - Zucknick, Manuela
AU  - Roessler, Stephanie
AU  - Mehrabi, Arianeb
AU  - Hafezi, Mohammadreza
AU  - Stenzinger, Albrecht
AU  - Warth, Arne
AU  - Pathil, Anita
AU  - Renner, Marcus
AU  - Schirmacher, Peter
AU  - Weichert, Wilko
TI  - Major histocompatibility complex class I expression impacts on patient survival and type and density of immune cells in biliary tract cancer.
JO  - British journal of cancer
VL  - 113
IS  - 9
SN  - 1532-1827
CY  - Edinburgh
PB  - Nature Publ. Group
M1  - DKFZ-2017-02628
SP  - 1343 - 1349
PY  - 2015
AB  - Biliary tract cancers (BTC) are rare malignant tumours with a poor prognosis. Previously, we have presented a detailed characterisation of the inflammatory infiltrate in BTC. Here, we analysed the impact of the expression of major histocompatibility complex class I (MHC I) on patient survival and the quantity, as well as the quality of tumour-infiltrating immune cell types in BTC.MHC I expression was assessed semi-quantitatively in 334 BTC, including extrahepatic (n=129) and intrahepatic cholangiocarcinomas (n=146), as well as adenocarcinomas of the gallbladder (n=59). In addition, 71 high-grade biliary intraepithelial lesions (BilIN 3) were included. Results were correlated with data on antitumour inflammation and investigated with respect to their association with clinicopathological variables and patient survival.BTC showed a wide spectrum of different MHC I expression patterns ranging from complete negativity in some tumours to strong homogenous expression in others. In BilIN 3, significantly higher MHC I expression levels were seen compared to invasive tumours (P=0.004). Patients with strong tumoural MHC I expression had a significantly higher overall survival probability (median survival benefit: 8 months; P=0.006). MHC I expression strongly correlated with the number of tumour-infiltrating T-lymphocytes (CD4(+) and CD8(+)) and macrophages.Differences of MHC I expression predict patient outcome and show correlations with specific components of the inflammatory infiltrate in BTC. These findings contribute to a better understanding of immune response and immune escape phenomena in cholangiocarcinogenesis.
KW  - Histocompatibility Antigens Class I (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26461054
C2  - pmc:PMC4815783
DO  - DOI:10.1038/bjc.2015.337
UR  - https://inrepo02.dkfz.de/record/126600
ER  -