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| Home > Publications database > Major histocompatibility complex class I expression impacts on patient survival and type and density of immune cells in biliary tract cancer. > print |
| 001 | 126600 | ||
| 005 | 20240228140835.0 | ||
| 024 | 7 | _ | |a 10.1038/bjc.2015.337 |2 doi |
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| 024 | 7 | _ | |a 1532-1827 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2017-02628 |
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| 100 | 1 | _ | |a Goeppert, Benjamin |b 0 |
| 245 | _ | _ | |a Major histocompatibility complex class I expression impacts on patient survival and type and density of immune cells in biliary tract cancer. |
| 260 | _ | _ | |a Edinburgh |c 2015 |b Nature Publ. Group |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521197722_1744 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Biliary tract cancers (BTC) are rare malignant tumours with a poor prognosis. Previously, we have presented a detailed characterisation of the inflammatory infiltrate in BTC. Here, we analysed the impact of the expression of major histocompatibility complex class I (MHC I) on patient survival and the quantity, as well as the quality of tumour-infiltrating immune cell types in BTC.MHC I expression was assessed semi-quantitatively in 334 BTC, including extrahepatic (n=129) and intrahepatic cholangiocarcinomas (n=146), as well as adenocarcinomas of the gallbladder (n=59). In addition, 71 high-grade biliary intraepithelial lesions (BilIN 3) were included. Results were correlated with data on antitumour inflammation and investigated with respect to their association with clinicopathological variables and patient survival.BTC showed a wide spectrum of different MHC I expression patterns ranging from complete negativity in some tumours to strong homogenous expression in others. In BilIN 3, significantly higher MHC I expression levels were seen compared to invasive tumours (P=0.004). Patients with strong tumoural MHC I expression had a significantly higher overall survival probability (median survival benefit: 8 months; P=0.006). MHC I expression strongly correlated with the number of tumour-infiltrating T-lymphocytes (CD4(+) and CD8(+)) and macrophages.Differences of MHC I expression predict patient outcome and show correlations with specific components of the inflammatory infiltrate in BTC. These findings contribute to a better understanding of immune response and immune escape phenomena in cholangiocarcinogenesis. |
| 536 | _ | _ | |a 313 - Cancer risk factors and prevention (POF3-313) |0 G:(DE-HGF)POF3-313 |c POF3-313 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Histocompatibility Antigens Class I |2 NLM Chemicals |
| 700 | 1 | _ | |a Frauenschuh, Lena |b 1 |
| 700 | 1 | _ | |a Zucknick, Manuela |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Roessler, Stephanie |b 3 |
| 700 | 1 | _ | |a Mehrabi, Arianeb |b 4 |
| 700 | 1 | _ | |a Hafezi, Mohammadreza |b 5 |
| 700 | 1 | _ | |a Stenzinger, Albrecht |b 6 |
| 700 | 1 | _ | |a Warth, Arne |b 7 |
| 700 | 1 | _ | |a Pathil, Anita |b 8 |
| 700 | 1 | _ | |a Renner, Marcus |b 9 |
| 700 | 1 | _ | |a Schirmacher, Peter |b 10 |
| 700 | 1 | _ | |a Weichert, Wilko |0 P:(DE-HGF)0 |b 11 |e Last author |
| 773 | _ | _ | |a 10.1038/bjc.2015.337 |g Vol. 113, no. 9, p. 1343 - 1349 |0 PERI:(DE-600)2002452-6 |n 9 |p 1343 - 1349 |t British journal of cancer |v 113 |y 2015 |x 1532-1827 |
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