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@ARTICLE{Gollhofer:126605,
      author       = {S. M. Gollhofer$^*$ and J. Wiskemann$^*$ and M. Schmidt$^*$
                      and O. Klassen$^*$ and C. M. Ulrich$^*$ and J. Oelmann and
                      H. Hof and K. Potthoff and K. Steindorf$^*$},
      title        = {{F}actors influencing participation in a randomized
                      controlled resistance exercise intervention study in breast
                      cancer patients during radiotherapy.},
      journal      = {BMC cancer},
      volume       = {15},
      number       = {1},
      issn         = {1471-2407},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2017-02633},
      pages        = {186},
      year         = {2015},
      abstract     = {Over the past years knowledge about benefits of physical
                      activity after cancer is evolving from randomized exercise
                      intervention trials. However, it has been argued that
                      results may be biased by selective participation. Therefore,
                      we investigated factors influencing participation in a
                      randomized exercise intervention trial for breast cancer
                      patients.Non-metastatic breast cancer patients were
                      systematically screened for a randomized exercise
                      intervention trial on cancer-related fatigue. Participants
                      and nonparticipants were compared concerning
                      sociodemographic characteristics (age, marital status,
                      living status, travel time to the training facility),
                      clinical data (body-mass-index, tumor stage, tumor size and
                      lymph node status, comorbidities, chemotherapy), fatigue,
                      and physical activity. Reasons for participation or
                      declination were recorded.117 patients (52 participants, 65
                      nonparticipants) were evaluable for analysis. Multiple
                      regression analyses revealed significantly higher odds to
                      decline participation among patients with longer travel time
                      (p=0.0012), living alone (p=0.039), with more comorbidities
                      (0.031), previous chemotherapy (p=0.0066), of age≥70 years
                      (p=0.025), or being free of fatigue (p=0.0007). No
                      associations were found with BMI or physical activity. By
                      far the most frequently reported reason for declination of
                      participation was too long commuting time to the training
                      facility.Willingness of breast cancer patients to
                      participate in a randomized exercise intervention study
                      differed by sociodemographic factors and health status.
                      Neither current physical activity level nor BMI appeared to
                      be selective for participation. Reduction of personal
                      inconveniences and time effort, e.g. by decentralized
                      training facilities or flexible training schedules, seem
                      most promising for enhancing participation in exercise
                      intervention trials.Registered at ClinicalTrials.gov:
                      NCT01468766 (October 2011).},
      keywords     = {Antineoplastic Agents (NLM Chemicals)},
      cin          = {G110 / G111 / D120},
      ddc          = {610},
      cid          = {I:(DE-He78)G110-20160331 / I:(DE-He78)G111-20160331 /
                      I:(DE-He78)D120-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25885634},
      pmc          = {pmc:PMC4466838},
      doi          = {10.1186/s12885-015-1213-1},
      url          = {https://inrepo02.dkfz.de/record/126605},
}