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@ARTICLE{Habl:126644,
      author       = {G. Habl and S. Katayama and M. Uhl and K. A. Kessel and L.
                      Edler$^*$ and J. Debus$^*$ and K. Herfarth and F.
                      Sterzing$^*$},
      title        = {{H}elical intensity-modulated radiotherapy of the pelvic
                      lymph nodes with a simultaneous integrated boost to the
                      prostate--first results of the {PLATIN} 1 trial.},
      journal      = {BMC cancer},
      volume       = {15},
      number       = {1},
      issn         = {1471-2407},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2017-02672},
      pages        = {868},
      year         = {2015},
      abstract     = {Definitive, percutaneous irradiation of the prostate and
                      the pelvic lymph nodes in high-risk prostate cancer is the
                      alternative to prostatectomy plus lymphadenectomy. To date,
                      the role of whole pelvis radiotherapy (WPRT) has not been
                      clarified especially taking into consideration the benefits
                      of high conformal IMRT (intensity modulated radiotherapy) of
                      complex-shaped target volumes.From 2009 to 2012, 40 patients
                      of high-risk prostate cancer with an increased risk of
                      microscopic lymph node involvement were enrolled into this
                      prospective phase II trial. Patients received at least two
                      months of antihormonal treatment (AT) before radiotherapy
                      continuing for at least 2 years. Helical IMRT (tomotherapy)
                      of the pelvic lymph nodes (51.0 Gy) with a simultaneous
                      integrated, moderate hypofractionated boost (single dose of
                      2.25 Gy) to the prostate (76.5 Gy) was performed in 34
                      fractions. PSA levels, prostate-related symptoms and quality
                      of life were assessed at regular intervals for 24 months.Of
                      the 40 patients enrolled, 38 finished the treatment as
                      planned. Overall acute toxicity rates were low and no acute
                      grade 3 or 4 gastrointestinal (GI) and genitourinary (GU)
                      toxicity occurred. $21.6\%$ of patients experienced acute
                      grade 2 but no late grade ≥ 2 GI toxicity. Regarding GU
                      side effects, results showed $48.6\%$ acute grade 2 and
                      $6.4\%$ late grade 2 toxicity. After a median observation
                      time of 23.4 months the PLATIN 1 trial can be considered as
                      sufficiently safe meeting the prospectively defined aims of
                      the trial. With 34/37 patients free of a PSA recurrence it
                      shows promising efficacy.Tomotherapy of the pelvic lymph
                      nodes with a simultaneous integrated boost to the prostate
                      can be performed safely and without excessive toxicity. The
                      combined irradiation of both prostate and pelvic lymph nodes
                      seems to be as well tolerated as the irradiation of the
                      prostate alone.Trial Numbers: ARO 2009-05,
                      ClinicalTrials.gov: NCT01903408.},
      cin          = {C060 / E050},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)E050-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26547188},
      pmc          = {pmc:PMC4637144},
      doi          = {10.1186/s12885-015-1886-5},
      url          = {https://inrepo02.dkfz.de/record/126644},
}