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@ARTICLE{Hamon:126658,
      author       = {J. Hamon and M. Renner and M. Jamei and A. Lukas and A.
                      Kopp-Schneider$^*$ and F. Y. Bois},
      title        = {{Q}uantitative in vitro to in vivo extrapolation of tissues
                      toxicity.},
      journal      = {Toxicology in vitro},
      volume       = {30},
      number       = {1 Pt A},
      issn         = {0887-2333},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2017-02686},
      pages        = {203 - 216},
      year         = {2015},
      abstract     = {Predicting repeated-dosing in vivo drug toxicity from in
                      vitro testing and omics data gathering requires significant
                      support in bioinformatics, mathematical modeling and
                      statistics. We present here the major aspects of the work
                      devoted within the framework of the European integrated
                      Predict-IV to pharmacokinetic modeling of in vitro
                      experiments, physiologically based pharmacokinetic (PBPK)
                      modeling, mechanistic models of toxicity for the kidney and
                      brain, large scale dose-response analyses methods and
                      biomarker discovery tools. All of those methods have been
                      applied to various extent to the drug datasets developed by
                      the project's partners. Our approach is rather generic and
                      could be adapted to other drugs or drug candidates. It marks
                      a successful integration of the work of the different teams
                      toward a common goal of predictive quantitative in vitro to
                      in vivo extrapolation.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25678044},
      doi          = {10.1016/j.tiv.2015.01.011},
      url          = {https://inrepo02.dkfz.de/record/126658},
}