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@ARTICLE{Hao:126665,
      author       = {S. Hao and C. Luo$^*$ and A. Abukiwan$^*$ and G. Wang and
                      J. He and L. Huang and C. E. M. Weber$^*$ and N. Lv and X.
                      Xiao and S. B. Eichmüller$^*$ and D. He},
      title        = {mi{R}-137 inhibits proliferation of melanoma cells by
                      targeting {PAK}2.},
      journal      = {Experimental dermatology},
      volume       = {24},
      number       = {12},
      issn         = {0906-6705},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2017-02693},
      pages        = {947 - 952},
      year         = {2015},
      abstract     = {MicroRNAs (miRNA) are key players in a variety of cancers
                      including malignant melanoma. miR-137 has been reported to
                      be a tumor suppressor in melanoma and several targets have
                      been identified for this miRNA. We previously developed a
                      novel proteomics technology, (35) S in vivo/vitro labelling
                      analysis for dynamic proteomics (SiLAD). Because of its high
                      sensitivity in analysing protein expression rates, SiLAD has
                      the potential to unravel miRNA effects on mRNAs coding for
                      proteins with long half-lives or high abundance. Using
                      SiLAD, we discovered that miR-137 significantly
                      downregulated the expression rate of p21-activated kinase 2
                      (PAK2) in melanoma cells. Bioinformatics analysis predicted
                      PAK2 as a direct target of miR-137, which was confirmed by
                      luciferase reporter assay and Western blot analysis. We
                      found that overexpression of miR-137 inhibited the
                      proliferation of melanoma cells, which could be phenocopied
                      by knockdown of PAK2 using siRNAs. Furthermore,
                      overexpression of PAK2 restored miR-137-mediated suppression
                      of cell proliferation. These findings indicate that miR-137
                      could inhibit proliferation through targeting PAK2 in
                      melanoma cells.},
      keywords     = {MIRN137 microRNA, human (NLM Chemicals) / MicroRNAs (NLM
                      Chemicals) / RNA, Neoplasm (NLM Chemicals) / RNA, Small
                      Interfering (NLM Chemicals) / PAK2 protein, human (NLM
                      Chemicals) / p21-Activated Kinases (NLM Chemicals)},
      cin          = {G183},
      ddc          = {610},
      cid          = {I:(DE-He78)G183-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26186482},
      doi          = {10.1111/exd.12812},
      url          = {https://inrepo02.dkfz.de/record/126665},
}