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@ARTICLE{Hmonnot:126708,
      author       = {C. Y. J. Hémonnot and M. Mauermann$^*$ and H. Herrmann$^*$
                      and S. Köster},
      title        = {{A}ssembly of {S}imple {E}pithelial {K}eratin {F}ilaments:
                      {D}eciphering the {I}on {D}ependence in {F}ilament
                      {O}rganization.},
      journal      = {Biomacromolecules},
      volume       = {16},
      number       = {10},
      issn         = {1526-4602},
      address      = {Columbus, Ohio},
      publisher    = {American Chemical Soc.},
      reportid     = {DKFZ-2017-02736},
      pages        = {3313 - 3321},
      year         = {2015},
      abstract     = {The intermediate filament proteins keratin K8 and K18
                      constitute an essential part of the cytoskeleton in simple
                      epithelial cell layers, structurally enforcing their
                      mechanical resistance. K8/K18 heterodimers form extended
                      filaments and higher-order structures including bundles and
                      networks that bind to cell junctions. We study the assembly
                      of these proteins in the presence of monovalent or divalent
                      ions by small-angle X-ray scattering. We find that both ion
                      species cause an increase of the filament diameter when
                      their concentration is increased; albeit, much higher values
                      are needed for the monovalent compared to the divalent ions
                      for the same effect. Bundling occurs also for monovalent
                      ions and at comparatively low concentrations of divalent
                      ions, very different from vimentin intermediate filaments, a
                      fibroblast-specific cytoskeleton component. We explain these
                      differences by variations in charge and hydrophobicity
                      patterns of the proteins. These differences may reflect the
                      respective physiological situation in stationary cell layers
                      versus single migrating fibroblasts.},
      keywords     = {Ions (NLM Chemicals) / Keratins (NLM Chemicals)},
      cin          = {B065},
      ddc          = {540},
      cid          = {I:(DE-He78)B065-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26327161},
      doi          = {10.1021/acs.biomac.5b00965},
      url          = {https://inrepo02.dkfz.de/record/126708},
}