%0 Journal Article
%A Hildebrandt, Wulf
%A Sauer, Roland
%A Bonaterra, Gabriel
%A Dugi, Klaus A
%A Edler, Lutz
%A Kinscherf, Ralf
%T Oral N-acetylcysteine reduces plasma homocysteine concentrations regardless of lipid or smoking status.
%J The American journal of clinical nutrition
%V 102
%N 5
%@ 1938-3207
%C Bethesda, Md.
%I Soc.
%M DKFZ-2017-02754
%P 1014 - 1024
%D 2015
%X Elevated total plasma homocysteine (tHcy) is considered to be an independent cardiovascular disease risk factor, although tHcy lowering by B-vitamins improves only certain clinical endpoints. N-acetylcysteine (NAC), a thiol-containing antioxidant, acutely lowers tHcy and possibly also blood pressure. However, to our knowledge, at present no conclusive long-term evaluation exists that controls for factors such as hyperlipidemia, smoking, medication, and disease stage, all of which affect the thiol redox state, including tHcy.We reanalyzed 2 double-blind, placebo-controlled trials in unmedicated middle-aged men, one in a hyperlipidemic group (HYL group; n = 40) and one in a normolipidemic group (NOL group; n = 42), each stratified for smokers and nonsmokers.We evaluated the effect of 4 wk of oral NAC (1.8 g/d) on tHcy (primary endpoint), plasma thiol (cysteine), and intracellular glutathione concentrations as well as on blood pressure. The HYL group had total cholesterol >220 mg/dL or triglycerides >150 mg/dL.NAC treatment significantly (P = 0.001, multivariate analysis of variance for repeated measures) lowered postabsorptive plasma concentrations of tHcy by -11.7
%K Antihypertensive Agents (NLM Chemicals)
%K Antioxidants (NLM Chemicals)
%K Triglycerides (NLM Chemicals)
%K Homocysteine (NLM Chemicals)
%K Cholesterol (NLM Chemicals)
%K Glutathione (NLM Chemicals)
%K Cysteine (NLM Chemicals)
%K Acetylcysteine (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26447155
%R 10.3945/ajcn.114.101964
%U https://inrepo02.dkfz.de/record/126726