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@ARTICLE{Jakobiec:126776,
      author       = {F. A. Jakobiec and M. Kool$^*$ and A. M. Stagner and S.
                      Pfister$^*$ and R. C. Eagle and A. D. Proia and A.
                      Korshunov$^*$},
      title        = {{I}ntraocular {M}edulloepitheliomas and {E}mbryonal
                      {T}umors {W}ith {M}ultilayered {R}osettes of the {B}rain:
                      {C}omparative {R}oles of {LIN}28{A} and {C}19{MC}.},
      journal      = {American journal of ophthalmology},
      volume       = {159},
      number       = {6},
      issn         = {0002-9394},
      address      = {New York, NY},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2017-02804},
      pages        = {1065 - 1074.e1},
      year         = {2015},
      abstract     = {To compare immunohistochemical and genetic overlaps and
                      differences between intraocular medulloepitheliomas and
                      embryonal tumors with multilayered rosettes of the
                      brain.Retrospective histopathologic, immunohistochemical,
                      and genetic analysis of 20 intraocular
                      medulloepitheliomas.(1) Review of clinical data and
                      hematoxylin-eosin-stained sections with (2)
                      immunohistochemical staining of paraffin sections using a
                      polyclonal antibody against the protein LIN28A, and (3)
                      fluorescence in situ hybridization (FISH) testing for the
                      amplification of the genetic locus 19q13.42 involving the
                      C19MC cluster of miRNA. Ten retinoblastomas served as
                      controls and to determine the specificity of these
                      biomarkers for intraocular medulloepitheliomas.Nineteen of
                      the 20 intraocular medulloepitheliomas were either diffusely
                      or focally LIN28A positive (weak, moderate, or strong). The
                      most intense positivity correlated with aggressive behavior
                      such as intraocular tissue invasion or extraocular
                      extension. None of the cases studied by FISH harbored an
                      amplicon for C19MC. The 10 retinoblastomas were LIN28A and
                      C19MC negative.LIN28A has a putative role in oncogenesis and
                      is found only in embryonic cells and malignancies.
                      Intraocular medulloepitheliomas and embryonal tumors with
                      multilayered rosettes of the brain both display LIN28A
                      positivity. Only the latter, however, display amplification
                      of the 19q13.42 locus involving C19MC, implying that other
                      causative factors are at play in intraocular
                      medulloepitheliomas. More aggressive tumor behavior within
                      the eye can be partially predicted by LIN28A staining
                      intensity.},
      keywords     = {Biomarkers, Tumor (NLM Chemicals) / LIN28B protein, human
                      (NLM Chemicals) / MicroRNAs (NLM Chemicals) / RNA-Binding
                      Proteins (NLM Chemicals)},
      cin          = {B062 / G380},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)G380-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25748578},
      doi          = {10.1016/j.ajo.2015.03.002},
      url          = {https://inrepo02.dkfz.de/record/126776},
}