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@ARTICLE{Johann:126797,
      author       = {P. Johann$^*$ and I. Müller},
      title        = {{M}ultipotent {M}esenchymal {S}tromal {C}ells: {P}ossible
                      {C}ulprits in {S}olid {T}umors?},
      journal      = {Stem cells international},
      volume       = {2015},
      issn         = {1687-9678},
      address      = {London [u.a.]},
      publisher    = {Sage-Hindawi},
      reportid     = {DKFZ-2017-02825},
      pages        = {914632},
      year         = {2015},
      abstract     = {The clinical use of bone marrow derived multipotent
                      mesenchymal stromal cells (BM-MSCs) in different settings
                      ranging from tissue engineering to immunotherapies has
                      prompted investigations on the properties of these cells in
                      a variety of other tissues. Particularly the role of MSCs in
                      solid tumors has been the subject of many experimental
                      approaches. While a clear phenotypical distinction of tumor
                      associated fibroblasts (TAFs) and MSCs within the tumor
                      microenvironment is still missing, the homing of bone marrow
                      MSCs in tumor sites has been extensively studied. Both,
                      tumor-promoting and tumor-inhibiting effects of BM-MSCs have
                      been described in this context. This ambiguity requires a
                      reappraisal of the different studies and experimental
                      methods employed. Here, we review the current literature on
                      tumor-promoting and tumor-inhibiting effects of BM-MSCs with
                      a particular emphasis on their interplay with components of
                      the immune system and also highlight a potential role of
                      MSCs as cell of origin for certain mesenchymal tumors.},
      cin          = {B062},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26273308},
      pmc          = {pmc:PMC4530290},
      doi          = {10.1155/2015/914632},
      url          = {https://inrepo02.dkfz.de/record/126797},
}