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| Home > Publications database > Helical intensity-modulated radiotherapy of the pelvic lymph nodes with integrated boost to the prostate bed - initial results of the PLATIN 3 Trial. > print |
| 001 | 126830 | ||
| 005 | 20240228135026.0 | ||
| 024 | 7 | _ | |a 10.1186/1471-2407-14-20 |2 doi |
| 024 | 7 | _ | |a pmid:24422782 |2 pmid |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Katayama, Sonja |b 0 |
| 245 | _ | _ | |a Helical intensity-modulated radiotherapy of the pelvic lymph nodes with integrated boost to the prostate bed - initial results of the PLATIN 3 Trial. |
| 260 | _ | _ | |a London |c 2014 |b BioMed Central |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1531220980_11486 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Adjuvant and salvage radiotherapy of the prostate bed are established treatment options for prostate cancer. While the benefit of an additional radiotherapy of the pelvic lymph nodes is still under debate, the PLATIN 3 prospective phase II clinical trial was initiated to substantiate toxicity data on postoperative IMRT of the pelvic lymph nodes and the prostate bed.From 2009 to 2011, 40 patients with high-risk prostate cancer after prostatectomy with pT3 R0/1 M0 or pT2 R1 M0 or a PSA recurrence and either > 20% risk of lymph node involvement and inadequate lymphadenectomy or pN + were enrolled. Patients received two months of antihormonal treatment (AT) before radiotherapy. AT continuation was mandatory during radiotherapy and was recommended for another two years. IMRT of the pelvic lymph nodes (51.0 Gy) with a simultaneous integrated boost to the prostate bed (68.0 Gy) was performed in 34 fractions. PSA level, prostate-related symptoms and quality of life were assessed at regular intervals for 24 months.Of the 40 patients enrolled, 39 finished treatment as planned. Overall acute toxicity rates were low and no acute grade 3/4 toxicity occurred. Only 22.5% of patients experienced acute grade 2 gastrointestinal (GI) and genitourinary (GU) toxicity. During follow-up, 10.0% late grade 2 GI and 5.0% late grade 2 GU toxicity occurred, and one patient developed late grade 3 proctitis and enteritis. After a median observation time of 24 months the PLATIN 3 trial has shown in 97.5% of all patients sufficient safety and thus met its prospectively defined aims. After a median of 24 months, 34/38 patients were free of a PSA recurrence.Postoperative whole-pelvis IMRT with an integrated boost to the prostate bed can be performed safely and without excessive toxicity. |
| 536 | _ | _ | |a 315 - Imaging and radiooncology (POF3-315) |0 G:(DE-HGF)POF3-315 |c POF3-315 |f POF III |x 0 |
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| 650 | _ | 7 | |a Androgen Antagonists |2 NLM Chemicals |
| 650 | _ | 7 | |a Antineoplastic Agents, Hormonal |2 NLM Chemicals |
| 650 | _ | 7 | |a Kallikreins |0 EC 3.4.21.- |2 NLM Chemicals |
| 650 | _ | 7 | |a kallikrein-related peptidase 3, human |0 EC 3.4.21.- |2 NLM Chemicals |
| 650 | _ | 7 | |a Prostate-Specific Antigen |0 EC 3.4.21.77 |2 NLM Chemicals |
| 700 | 1 | _ | |a Habl, Gregor |b 1 |
| 700 | 1 | _ | |a Kessel, Kerstin |b 2 |
| 700 | 1 | _ | |a Edler, Lutz |0 P:(DE-He78)621efe295db6fdfa7f9f95011a5ea943 |b 3 |u dkfz |
| 700 | 1 | _ | |a Debus, Juergen |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Herfarth, Klaus |b 5 |
| 700 | 1 | _ | |a Sterzing, Florian |0 P:(DE-He78)75d45845a04db67c5a88db1086046ef1 |b 6 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1186/1471-2407-14-20 |g Vol. 14, no. 1, p. 20 |0 PERI:(DE-600)2041352-X |n 1 |p 20 |t BMC cancer |v 14 |y 2014 |x 1471-2407 |
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