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@ARTICLE{Kather:126832,
      author       = {J. N. Kather and J. Kroll$^*$},
      title        = {{T}ransgenic mouse models of corneal neovascularization:
                      new perspectives for angiogenesis research.},
      journal      = {Investigative ophthalmology $\&$ visual science},
      volume       = {55},
      number       = {11},
      issn         = {1552-5783},
      address      = {Rockville, Md.},
      publisher    = {ARVO},
      reportid     = {DKFZ-2017-02860},
      pages        = {7637},
      year         = {2014},
      abstract     = {Corneal neovascularization (NV) refers to the growth of
                      blood vessels and/or lymphatics into the physiologically
                      avascular cornea, which occurs in several pathological
                      processes. In mouse models, corneal NV can be artificially
                      induced to investigate mechanisms of corneal pathologies.
                      However, mouse models of corneal NV are not restricted to
                      cornea-specific research, but also are widely used to
                      investigate general mechanisms of angiogenesis. Because the
                      cornea is transparent and easily accessible, corneal NV
                      models are among the most useful in vivo models in
                      angiogenesis research. The three different approaches that
                      are used to study corneal NV in mice are based on direct
                      application of proangiogenic or antiangiogenic transmitters,
                      external injury to the cornea, or genetically engineered
                      mice, which spontaneously develop corneal NV. The aim of
                      this review is to compare the scope and limitations of the
                      different approaches for corneal NV in mice. Our main focus
                      is to highlight the potential of transgenic spontaneous
                      models of corneal NV. Transgenic models do not require any
                      experimental interference and make it possible to
                      investigate different interconnected proangiogenic signaling
                      cascades. As a result, transgenic models are highly useful
                      for disease-centered angiogenesis research. In summary,
                      transgenic models of corneal NV will complement and advance
                      existing ocular NV assays, and help to discover new
                      angiogenesis-related treatment strategies for ocular and
                      extraocular diseases.},
      keywords     = {Biomarkers (NLM Chemicals) / Vascular Endothelial Growth
                      Factor A (NLM Chemicals) / RNA (NLM Chemicals)},
      cin          = {A190},
      ddc          = {610},
      cid          = {I:(DE-He78)A190-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25425566},
      doi          = {10.1167/iovs.14-15430},
      url          = {https://inrepo02.dkfz.de/record/126832},
}