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@ARTICLE{Kawka:126835,
      author       = {J. Kawka and D. Sturm$^*$ and S. Pleier$^*$ and S.
                      Pfister$^*$ and A. Marciniak-Czochra},
      title        = {{R}evealing the role of {SGK}1 in the dynamics of
                      medulloblastoma using a mathematical model.},
      journal      = {Journal of theoretical biology},
      volume       = {354},
      issn         = {0022-5193},
      address      = {London},
      publisher    = {Academic Press},
      reportid     = {DKFZ-2017-02863},
      pages        = {105 - 112},
      year         = {2014},
      abstract     = {Deregulation of signaling pathways and subsequent abnormal
                      interactions of downstream genes very often results in
                      carcinogenesis. In this paper, we propose a two-compartment
                      model describing intricate dynamics of the target genes of
                      the Wnt signaling pathway in medulloblastoma. The system of
                      nine nonlinear ordinary differential equations accounts for
                      the formation and dissociation of complexes as well as for
                      the transcription, translation and transport between the
                      cytoplasm and the nucleus. We focus on the interplay between
                      MYC and SGK1 (serum and glucocorticoid-inducible kinase 1),
                      which are the products of Wnt/β-catenin signaling pathway,
                      and GSK3β (glycogen synthase kinase). Numerical simulations
                      of the model solutions yield a better understanding of the
                      process and indicate the importance of the SGK1 gene in the
                      development of medulloblastoma, which has been confirmed in
                      our recent experiments. The model is calibrated based on the
                      gene expression microarray data for two types of
                      medulloblastoma, characterized by monosomy and trisomy of
                      chromosome 6q to highlight the difference between
                      diagnoses.},
      keywords     = {Immediate-Early Proteins (NLM Chemicals) / MYC protein,
                      human (NLM Chemicals) / Proto-Oncogene Proteins c-myc (NLM
                      Chemicals) / Protein-Serine-Threonine Kinases (NLM
                      Chemicals) / serum-glucocorticoid regulated kinase (NLM
                      Chemicals)},
      cin          = {B062},
      ddc          = {570},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24685888},
      doi          = {10.1016/j.jtbi.2014.03.028},
      url          = {https://inrepo02.dkfz.de/record/126835},
}