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@ARTICLE{Kiesow:126873,
      author       = {K. Kiesow$^*$ and K. Bennewitz$^*$ and L. G. Miranda$^*$
                      and S. J. Stoll$^*$ and B. Hartenstein$^*$ and P. Angel$^*$
                      and J. Kroll$^*$ and M. Schorpp-Kistner$^*$},
      title        = {{J}unb controls lymphatic vascular development in zebrafish
                      via mi{R}-182.},
      journal      = {Scientific reports},
      volume       = {5},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2017-02901},
      pages        = {15007 -},
      year         = {2015},
      abstract     = {JUNB, a subunit of the AP-1 transcription factor complex,
                      mediates gene regulation in response to a plethora of
                      extracellular stimuli. Previously, JUNB was shown to act as
                      a critical positive regulator of blood vessel development
                      and homeostasis as well as a negative regulator of
                      proliferation, inflammation and tumour growth. Here, we
                      demonstrate that the oncogenic miR-182 is a novel JUNB
                      target. Loss-of-function studies by morpholino-mediated
                      knockdown and the CRISPR/Cas9 technology identify a novel
                      function for both JUNB and its target miR-182 in lymphatic
                      vascular development in zebrafish. Furthermore, we show that
                      miR-182 attenuates foxo1 expression indicating that strictly
                      balanced Foxo1 levels are required for proper lymphatic
                      vascular development in zebrafish. In conclusion, our
                      findings uncover with the Junb/miR-182/Foxo1 regulatory axis
                      a novel key player in governing lymphatic vascular
                      morphogenesis in zebrafish.},
      keywords     = {Forkhead Box Protein O1 (NLM Chemicals) / Forkhead
                      Transcription Factors (NLM Chemicals) / FoxO1 protein,
                      zebrafish (NLM Chemicals) / MicroRNAs (NLM Chemicals) /
                      Proto-Oncogene Proteins c-jun (NLM Chemicals) / Zebrafish
                      Proteins (NLM Chemicals)},
      cin          = {A100 / A190},
      ddc          = {000},
      cid          = {I:(DE-He78)A100-20160331 / I:(DE-He78)A190-20160331},
      pnm          = {321 - Basic Concepts (POF3-321)},
      pid          = {G:(DE-HGF)POF3-321},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26458334},
      pmc          = {pmc:PMC4602192},
      doi          = {10.1038/srep15007},
      url          = {https://inrepo02.dkfz.de/record/126873},
}