% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Korshunov:126905,
      author       = {A. Korshunov$^*$ and F. A. Jakobiec and C. G. Eberhart and
                      V. Hovestadt$^*$ and D. Capper$^*$ and D. Jones$^*$ and D.
                      Sturm$^*$ and A. M. Stagner and D. P. Edward and R. C. Eagle
                      and A. D. Proia and A. Koch and M. Ryzhova and A. Ektova and
                      U. Schüller and O. Zheludkova and P. Lichter$^*$ and A. von
                      Deimling$^*$ and S. Pfister$^*$ and M. Kool$^*$},
      title        = {{C}omparative integrated molecular analysis of intraocular
                      medulloepitheliomas and central nervous system embryonal
                      tumors with multilayered rosettes confirms that they are
                      distinct nosologic entities.},
      journal      = {Neuropathology},
      volume       = {35},
      number       = {6},
      issn         = {0919-6544},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2017-02933},
      pages        = {538 - 544},
      year         = {2015},
      abstract     = {Intraocular medulloepithelioma (IO MEPL) is an uncommon
                      embryonal neuroepithelial neoplasm of the eye. These ocular
                      neoplasms have been compared with intracranial
                      medulloepitheliomas or other histologic variants of CNS
                      embryonal tumor with multilayered rosettes (CNS ETMR) due to
                      their morphological mimicry. We performed comprehensive
                      molecular analysis to explore the histogenetic and biologic
                      relationships between 22 IO MEPL and 68 CNS ETMR. Routinely
                      prepared paraffin-embedded samples were assessed for
                      genome-wide methylation profiles using the Illumina
                      Methylation 450k BeadChip array. We identified strong
                      cytogenetic and epigenetic differences between ocular
                      neoplasms and CNS ETMR. None of the IO MEPL cases displayed
                      the ETMR-specific amplification of the C19MC locus. Instead,
                      cytogenetic analysis of the IO MEPL showed numerous copy
                      number aberrations which involved either whole chromosomes
                      or chromosomal arms; recurrent aberrations in these tumors
                      affected chromosomes 1p, 4, 8 and 16p. DNA methylation
                      patterns were also strikingly different between these two
                      tumor entities, suggesting that they do not share common
                      origins and biological behaviors. Comparative cluster
                      analysis of 198 pediatric CNS tumors and 22 IO MEPL revealed
                      a clear demarcation of the CNS ETMR and IO MEPL profiles
                      from other CNS entities. In conclusion, although IO MEPL
                      shares some histopathological features with CNS ETMR, they
                      manifest striking molecular diversity at the cytogenetic and
                      epigenetic levels. Consequently they deserve a separate
                      nosologic designation in future tumor classifications, where
                      CNS MEPL could be designated as a histological variant of
                      CNS ETMR.},
      cin          = {G380 / B060 / B062 / L101 / L701},
      ddc          = {610},
      cid          = {I:(DE-He78)G380-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)L101-20160331 /
                      I:(DE-He78)L701-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26183384},
      doi          = {10.1111/neup.12227},
      url          = {https://inrepo02.dkfz.de/record/126905},
}