%0 Journal Article
%A Korshunov, Andrey
%A Ryzhova, Marina
%A Hovestadt, Volker
%A Bender, Sebastian
%A Sturm, Dominik
%A Capper, David
%A Meyer, Jochen
%A Schrimpf, Daniel
%A Kool, Marcel
%A Northcott, Paul A
%A Zheludkova, Olga
%A Milde, Till
%A Witt, Olaf
%A Kulozik, Andreas E
%A Reifenberger, Guido
%A Jabado, Nada
%A Perry, Arie
%A Lichter, Peter
%A von Deimling, Andreas
%A Pfister, Stefan
%A Jones, David
%T Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers.
%J Acta neuropathologica
%V 129
%N 5
%@ 1432-0533
%C Berlin
%I Springer
%M DKFZ-2017-02934
%P 669 - 678
%D 2015
%X Pediatric glioblastoma (pedGBM) is amongst the most common malignant brain tumors of childhood and carries a dismal prognosis. In contrast to adult GBM, few molecular prognostic markers for the pediatric counterpart have been established. We, therefore, investigated the prognostic significance of genomic and epigenetic alterations through molecular analysis of 202 pedGBM (1-18 years) with comprehensive clinical annotation. Routinely prepared formalin-fixed paraffin-embedded tumor samples were assessed for genome-wide DNA methylation profiles, with known candidate genes screened for alterations via direct sequencing or FISH. Unexpectedly, a subset of histologically diagnosed GBM (n = 40, 20 
%K Biomarkers, Tumor (NLM Chemicals)
%K Proto-Oncogene Proteins B-raf (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25752754
%R 10.1007/s00401-015-1405-4
%U https://inrepo02.dkfz.de/record/126906