TY  - JOUR
AU  - Korshunov, Andrey
AU  - Ryzhova, Marina
AU  - Hovestadt, Volker
AU  - Bender, Sebastian
AU  - Sturm, Dominik
AU  - Capper, David
AU  - Meyer, Jochen
AU  - Schrimpf, Daniel
AU  - Kool, Marcel
AU  - Northcott, Paul A
AU  - Zheludkova, Olga
AU  - Milde, Till
AU  - Witt, Olaf
AU  - Kulozik, Andreas E
AU  - Reifenberger, Guido
AU  - Jabado, Nada
AU  - Perry, Arie
AU  - Lichter, Peter
AU  - von Deimling, Andreas
AU  - Pfister, Stefan
AU  - Jones, David
TI  - Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers.
JO  - Acta neuropathologica
VL  - 129
IS  - 5
SN  - 1432-0533
CY  - Berlin
PB  - Springer
M1  - DKFZ-2017-02934
SP  - 669 - 678
PY  - 2015
AB  - Pediatric glioblastoma (pedGBM) is amongst the most common malignant brain tumors of childhood and carries a dismal prognosis. In contrast to adult GBM, few molecular prognostic markers for the pediatric counterpart have been established. We, therefore, investigated the prognostic significance of genomic and epigenetic alterations through molecular analysis of 202 pedGBM (1-18 years) with comprehensive clinical annotation. Routinely prepared formalin-fixed paraffin-embedded tumor samples were assessed for genome-wide DNA methylation profiles, with known candidate genes screened for alterations via direct sequencing or FISH. Unexpectedly, a subset of histologically diagnosed GBM (n = 40, 20 
KW  - Biomarkers, Tumor (NLM Chemicals)
KW  - Proto-Oncogene Proteins B-raf (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25752754
DO  - DOI:10.1007/s00401-015-1405-4
UR  - https://inrepo02.dkfz.de/record/126906
ER  -