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@ARTICLE{Kuehl:126939,
      author       = {R. Kuehl$^*$ and F. Scharhag-Rosenberger$^*$ and K.
                      Schommer and M. Schmidt$^*$ and P. Dreger and G. Huber and
                      M. Bohus and C. M. Ulrich and J. Wiskemann$^*$},
      title        = {{E}xercise intensity classification in cancer patients
                      undergoing allogeneic {HCT}.},
      journal      = {Medicine and science in sports and exercise},
      volume       = {47},
      number       = {5},
      issn         = {0195-9131},
      address      = {Philadelphia, Pa.},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {DKFZ-2017-02967},
      pages        = {889 - 895},
      year         = {2015},
      abstract     = {Exercise intervention studies during and after cancer
                      treatment show beneficial effects for various physical and
                      psychosocial outcomes. Current exercise intensity guidelines
                      for cancer patients are rather general and have been adapted
                      from American College of Sports Medicine (ACSM)
                      recommendations for healthy individuals. Intensive cancer
                      treatment regimens such as allogeneic hematopoietic stem
                      cell transplantation (allo-HCT) may change the
                      cardiovascular response to acute exercise. Therefore, we
                      evaluated the relationships between $\%V˙O2$ reserve
                      $(\%V˙O2R,$ reference) and $\%HRR,$ $\%HRmax,$ and
                      $\%V˙O2max$ and compared calculated intensities with given
                      intensities by ACSM.Measurements before and 180 d after
                      allo-HCT from a randomized controlled trial were used. Only
                      patients who reached maximal effort and at least two
                      exercise stages in our maximal incremental cycling test were
                      included. Before allo-HCT, 106 patients were included, and
                      180 d after treatment, 49 patients met our inclusion
                      criteria. Individual regression lines were calculated with
                      V˙O2R as the reference. Calculated exercise intensities for
                      endurance training prescription were compared with ACSM
                      values.Before allo-HCT, $\%HRR$ values of patients were
                      significantly lower than ACSM values, and $\%HRmax$ and
                      $\%V˙O2max$ values were significantly higher (except $90\%$
                      HRmax, which was significantly lower, all P < 0.01). One
                      hundred eighty days after allo-HCT, values for $\%HRR$ were
                      not significantly different to ACSM values (except $90\%,$
                      which was significantly lower, P = 0.01), whereas $\%HRmax$
                      and $\%V˙O2max$ were significantly higher (all P < 0.05).
                      Furthermore, regression models revealed no influence of
                      beta-blockers on calculated intensities.ACSM's exercise
                      intensity recommendations for endurance training may not be
                      applicable for cancer patients during and 180 d after
                      allo-HCT because they may not meet the targeted intensity
                      class, with the exception of $\%HRR$ 180 d after allo-HCT.},
      cin          = {G110 / D120 / G111},
      ddc          = {610},
      cid          = {I:(DE-He78)G110-20160331 / I:(DE-He78)D120-20160331 /
                      I:(DE-He78)G111-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25202849},
      doi          = {10.1249/MSS.0000000000000498},
      url          = {https://inrepo02.dkfz.de/record/126939},
}