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000126989 0247_ $$2doi$$a10.1002/ijc.28719
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000126989 0247_ $$2ISSN$$a0020-7136
000126989 0247_ $$2ISSN$$a1097-0215
000126989 037__ $$aDKFZ-2017-03015
000126989 041__ $$aeng
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000126989 1001_ $$aKerl, Kornelius$$b0
000126989 245__ $$aArsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1.
000126989 260__ $$aBognor Regis$$bWiley-Liss$$c2014
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000126989 520__ $$aRhabdoid tumors are highly aggressive tumors occurring in infants and very young children. Despite multimodal and intensive therapy prognosis remains poor. Molecular analyses have uncovered several deregulated pathways, among them the CDK4/6-Rb-, the WNT- and the Sonic hedgehog (SHH) pathways. The SHH pathway is activated in rhabdoid tumors by GLI1 overexpression. Here, we demonstrate that arsenic trioxide (ATO) inhibits tumor cell growth of malignant rhabdoid tumors in vitro and in a mouse xenograft model by suppressing Gli1. Our data uncover ATO as a promising therapeutic approach to improve prognosis for rhabdoid tumor patients.
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000126989 650_7 $$2NLM Chemicals$$aAntineoplastic Agents
000126989 650_7 $$2NLM Chemicals$$aArsenicals
000126989 650_7 $$2NLM Chemicals$$aGLI1 protein, human
000126989 650_7 $$2NLM Chemicals$$aGli protein, mouse
000126989 650_7 $$2NLM Chemicals$$aHedgehog Proteins
000126989 650_7 $$2NLM Chemicals$$aKruppel-Like Transcription Factors
000126989 650_7 $$2NLM Chemicals$$aOxides
000126989 650_7 $$2NLM Chemicals$$aSHH protein, human
000126989 650_7 $$2NLM Chemicals$$aTranscription Factors
000126989 650_7 $$2NLM Chemicals$$aZinc Finger Protein GLI1
000126989 650_7 $$0S7V92P67HO$$2NLM Chemicals$$aarsenic trioxide
000126989 7001_ $$aMoreno, Natalia$$b1
000126989 7001_ $$aHolsten, Till$$b2
000126989 7001_ $$aAhlfeld, Julia$$b3
000126989 7001_ $$aMertins, Julius$$b4
000126989 7001_ $$aHotfilder, Marc$$b5
000126989 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b6$$udkfz
000126989 7001_ $$aBartelheim, Kerstin$$b7
000126989 7001_ $$aSchleicher, Sabine$$b8
000126989 7001_ $$aHandgretinger, Rupert$$b9
000126989 7001_ $$aSchüller, Ulrich$$b10
000126989 7001_ $$aMeisterernst, Michael$$b11
000126989 7001_ $$aFrühwald, Michael C$$b12
000126989 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.28719$$gVol. 135, no. 4, p. 989 - 995$$n4$$p989 - 995$$tInternational journal of cancer$$v135$$x0020-7136$$y2014
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000126989 9141_ $$y2014
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