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| Home > Publications database > Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1. > print |
| Home > Publications database > Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1. > print |
| 001 | 126989 | ||
| 005 | 20240228135028.0 | ||
| 024 | 7 | _ | |a 10.1002/ijc.28719 |2 doi |
| 024 | 7 | _ | |a pmid:24420698 |2 pmid |
| 024 | 7 | _ | |a 0020-7136 |2 ISSN |
| 024 | 7 | _ | |a 1097-0215 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2017-03015 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Kerl, Kornelius |b 0 |
| 245 | _ | _ | |a Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1. |
| 260 | _ | _ | |a Bognor Regis |c 2014 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1506000063_16804 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Rhabdoid tumors are highly aggressive tumors occurring in infants and very young children. Despite multimodal and intensive therapy prognosis remains poor. Molecular analyses have uncovered several deregulated pathways, among them the CDK4/6-Rb-, the WNT- and the Sonic hedgehog (SHH) pathways. The SHH pathway is activated in rhabdoid tumors by GLI1 overexpression. Here, we demonstrate that arsenic trioxide (ATO) inhibits tumor cell growth of malignant rhabdoid tumors in vitro and in a mouse xenograft model by suppressing Gli1. Our data uncover ATO as a promising therapeutic approach to improve prognosis for rhabdoid tumor patients. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Antineoplastic Agents |2 NLM Chemicals |
| 650 | _ | 7 | |a Arsenicals |2 NLM Chemicals |
| 650 | _ | 7 | |a GLI1 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Gli protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Hedgehog Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Kruppel-Like Transcription Factors |2 NLM Chemicals |
| 650 | _ | 7 | |a Oxides |2 NLM Chemicals |
| 650 | _ | 7 | |a SHH protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Transcription Factors |2 NLM Chemicals |
| 650 | _ | 7 | |a Zinc Finger Protein GLI1 |2 NLM Chemicals |
| 650 | _ | 7 | |a arsenic trioxide |0 S7V92P67HO |2 NLM Chemicals |
| 700 | 1 | _ | |a Moreno, Natalia |b 1 |
| 700 | 1 | _ | |a Holsten, Till |b 2 |
| 700 | 1 | _ | |a Ahlfeld, Julia |b 3 |
| 700 | 1 | _ | |a Mertins, Julius |b 4 |
| 700 | 1 | _ | |a Hotfilder, Marc |b 5 |
| 700 | 1 | _ | |a Kool, Marcel |0 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |b 6 |u dkfz |
| 700 | 1 | _ | |a Bartelheim, Kerstin |b 7 |
| 700 | 1 | _ | |a Schleicher, Sabine |b 8 |
| 700 | 1 | _ | |a Handgretinger, Rupert |b 9 |
| 700 | 1 | _ | |a Schüller, Ulrich |b 10 |
| 700 | 1 | _ | |a Meisterernst, Michael |b 11 |
| 700 | 1 | _ | |a Frühwald, Michael C |b 12 |
| 773 | _ | _ | |a 10.1002/ijc.28719 |g Vol. 135, no. 4, p. 989 - 995 |0 PERI:(DE-600)1474822-8 |n 4 |p 989 - 995 |t International journal of cancer |v 135 |y 2014 |x 0020-7136 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:126989 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 6 |6 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |
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