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000127014 0247_ $$2doi$$a10.1016/j.tiv.2014.12.011
000127014 0247_ $$2pmid$$apmid:25596134
000127014 0247_ $$2ISSN$$a0887-2333
000127014 0247_ $$2ISSN$$a1879-3177
000127014 037__ $$aDKFZ-2017-03040
000127014 041__ $$aeng
000127014 082__ $$a610
000127014 1001_ $$aLimonciel, Alice$$b0
000127014 245__ $$aTranscriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing.
000127014 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2015
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000127014 520__ $$aHigh content omic methods provide a deep insight into cellular events occurring upon chemical exposure of a cell population or tissue. However, this improvement in analytic precision is not yet matched by a thorough understanding of molecular mechanisms that would allow an optimal interpretation of these biological changes. For transcriptomics (TCX), one type of molecular effects that can be assessed already is the modulation of the transcriptional activity of a transcription factor (TF). As more ChIP-seq datasets reporting genes specifically bound by a TF become publicly available for mining, the generation of target gene lists of TFs of toxicological relevance becomes possible, based on actual protein-DNA interaction and modulation of gene expression. In this study, we generated target gene signatures for Nrf2, ATF4, XBP1, p53, HIF1a, AhR and PPAR gamma and tracked TF modulation in a large collection of in vitro TCX datasets from renal and hepatic cell models exposed to clinical nephro- and hepato-toxins. The result is a global monitoring of TF modulation with great promise as a mechanistically based tool for chemical hazard identification.
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000127014 650_7 $$2NLM Chemicals$$aHazardous Substances
000127014 650_7 $$2NLM Chemicals$$aLigands
000127014 650_7 $$2NLM Chemicals$$aTranscription Factors
000127014 7001_ $$aMoenks, Konrad$$b1
000127014 7001_ $$aStanzel, Sven$$b2
000127014 7001_ $$aTruisi, Germaine L$$b3
000127014 7001_ $$aParmentier, Céline$$b4
000127014 7001_ $$aAschauer, Lydia$$b5
000127014 7001_ $$aWilmes, Anja$$b6
000127014 7001_ $$aRichert, Lysiane$$b7
000127014 7001_ $$aHewitt, Philip$$b8
000127014 7001_ $$aMueller, Stefan O$$b9
000127014 7001_ $$aLukas, Arno$$b10
000127014 7001_ $$0P:(DE-He78)bb6a7a70f976eb8df1769944bf913596$$aKopp-Schneider, Annette$$b11$$udkfz
000127014 7001_ $$aLeonard, Martin O$$b12
000127014 7001_ $$aJennings, Paul$$b13
000127014 773__ $$0PERI:(DE-600)1501079-x$$a10.1016/j.tiv.2014.12.011$$gVol. 30, no. 1 Pt A, p. 7 - 18$$n1 Pt A$$p7 - 18$$tToxicology in vitro$$v30$$x0887-2333$$y2015
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000127014 9141_ $$y2015
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