TY  - JOUR
AU  - Lowery, Jason
AU  - Kuczmarski, Edward R
AU  - Herrmann, Harald
AU  - Goldman, Robert D
TI  - Intermediate Filaments Play a Pivotal Role in Regulating Cell Architecture and Function.
JO  - The journal of biological chemistry
VL  - 290
IS  - 28
SN  - 1083-351X
CY  - Bethesda, Md.
PB  - Soc.
M1  - DKFZ-2017-03060
SP  - 17145 - 17153
PY  - 2015
AB  - Intermediate filaments (IFs) are composed of one or more members of a large family of cytoskeletal proteins, whose expression is cell- and tissue type-specific. Their importance in regulating the physiological properties of cells is becoming widely recognized in functions ranging from cell motility to signal transduction. IF proteins assemble into nanoscale biopolymers with unique strain-hardening properties that are related to their roles in regulating the mechanical integrity of cells. Furthermore, mutations in the genes encoding IF proteins cause a wide range of human diseases. Due to the number of different types of IF proteins, we have limited this short review to cover structure and function topics mainly related to the simpler homopolymeric IF networks composed of vimentin, and specifically for diseases, the related muscle-specific desmin IF networks.
KW  - Desmin (NLM Chemicals)
KW  - Intermediate Filament Proteins (NLM Chemicals)
KW  - Vimentin (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25957409
C2  - pmc:PMC4498054
DO  - DOI:10.1074/jbc.R115.640359
UR  - https://inrepo02.dkfz.de/record/127034
ER  -