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@ARTICLE{Lowery:127034,
      author       = {J. Lowery and E. R. Kuczmarski and H. Herrmann$^*$ and R.
                      D. Goldman},
      title        = {{I}ntermediate {F}ilaments {P}lay a {P}ivotal {R}ole in
                      {R}egulating {C}ell {A}rchitecture and {F}unction.},
      journal      = {The journal of biological chemistry},
      volume       = {290},
      number       = {28},
      issn         = {1083-351X},
      address      = {Bethesda, Md.},
      publisher    = {Soc.},
      reportid     = {DKFZ-2017-03060},
      pages        = {17145 - 17153},
      year         = {2015},
      abstract     = {Intermediate filaments (IFs) are composed of one or more
                      members of a large family of cytoskeletal proteins, whose
                      expression is cell- and tissue type-specific. Their
                      importance in regulating the physiological properties of
                      cells is becoming widely recognized in functions ranging
                      from cell motility to signal transduction. IF proteins
                      assemble into nanoscale biopolymers with unique
                      strain-hardening properties that are related to their roles
                      in regulating the mechanical integrity of cells.
                      Furthermore, mutations in the genes encoding IF proteins
                      cause a wide range of human diseases. Due to the number of
                      different types of IF proteins, we have limited this short
                      review to cover structure and function topics mainly related
                      to the simpler homopolymeric IF networks composed of
                      vimentin, and specifically for diseases, the related
                      muscle-specific desmin IF networks.},
      keywords     = {Desmin (NLM Chemicals) / Intermediate Filament Proteins
                      (NLM Chemicals) / Vimentin (NLM Chemicals)},
      cin          = {B065},
      ddc          = {570},
      cid          = {I:(DE-He78)B065-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25957409},
      pmc          = {pmc:PMC4498054},
      doi          = {10.1074/jbc.R115.640359},
      url          = {https://inrepo02.dkfz.de/record/127034},
}