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@ARTICLE{Mai:127047,
      author       = {E. K. Mai and T. Hielscher$^*$ and J. K. Kloth$^*$ and M.
                      Merz$^*$ and S. Shah and M.-S. Raab$^*$ and M. Hillengass
                      and B. Wagner and A. Jauch and D. Hose and M.-A. Weber$^*$
                      and S. Delorme$^*$ and H. Goldschmidt and J. Hillengass$^*$},
      title        = {{A} magnetic resonance imaging-based prognostic scoring
                      system to predict outcome in transplant-eligible patients
                      with multiple myeloma.},
      journal      = {Haematologica},
      volume       = {100},
      number       = {6},
      issn         = {1592-8721},
      address      = {Pavia},
      publisher    = {Ferrata Storti Foundation},
      reportid     = {DKFZ-2017-03073},
      pages        = {818 - 825},
      year         = {2015},
      abstract     = {Diffuse and focal bone marrow infiltration patterns
                      detected by magnetic resonance imaging have been shown to be
                      of prognostic significance in all stages of monoclonal
                      plasma cell disorders and have, therefore, been incorporated
                      into the definition of the disease. The aim of this
                      retrospective analysis was to develop a rapidly evaluable
                      prognostic scoring system, incorporating the most
                      significant information acquired from magnetic resonance
                      imaging. Therefore, the impact of bone marrow infiltration
                      patterns on progression-free and overall survival in 161
                      transplant-eligible myeloma patients was evaluated. Compared
                      to salt and pepper/minimal diffuse infiltration,
                      moderate/severe diffuse infiltration had a negative
                      prognostic impact on both progression-free survival
                      (P<0.001) and overall survival (P=0.003). More than 25 focal
                      lesions on whole-body magnetic resonance imaging or more
                      than seven on axial magnetic resonance imaging were
                      associated with an adverse prognosis (progression-free
                      survival: P=0.001/0.003 and overall survival: P=0.04/0.02).
                      A magnetic resonance imaging-based prognostic scoring
                      system, combining grouped diffuse and focal infiltration
                      patterns, was formulated and is applicable to whole-body as
                      well as axial magnetic resonance imaging. The score
                      identified high-risk patients with median progression-free
                      and overall survival of 23.4 and 55.9 months, respectively
                      (whole-body-based). Multivariate analyses demonstrated that
                      the magnetic resonance imaging-based prognostic score stage
                      III (high-risk) and adverse cytogenetics are independent
                      prognostic factors for both progression-free and overall
                      survival (whole-body-based, progression-free survival:
                      hazard ratio=3.65, P<0.001; overall survival: hazard
                      ratio=5.19, P=0.005). In conclusion, we suggest a magnetic
                      resonance imaging-based prognostic scoring system which is a
                      robust, easy to assess and interpret parameter summarizing
                      significant magnetic resonance imaging findings in
                      transplant-eligible patients with multiple myeloma.},
      cin          = {C060 / E010 / G170},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)E010-20160331 /
                      I:(DE-He78)G170-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25795721},
      pmc          = {pmc:PMC4450628},
      doi          = {10.3324/haematol.2015.124115},
      url          = {https://inrepo02.dkfz.de/record/127047},
}