%0 Journal Article
%A Merino, Diana M
%A Shlien, Adam
%A Villani, Anita
%A Pienkowska, Malgorzata
%A Mack, Stephen
%A Ramaswamy, Vijay
%A Shih, David
%A Tatevossian, Ruth
%A Novokmet, Ana
%A Choufani, Sanaa
%A Dvir, Rina
%A Ben-Arush, Myran
%A Harris, Brent T
%A Hwang, Eugene I
%A Lulla, Rishi
%A Pfister, Stefan
%A Achatz, Maria Isabel
%A Jabado, Nada
%A Finlay, Jonathan L
%A Weksberg, Rosanna
%A Bouffet, Eric
%A Hawkins, Cynthia
%A Taylor, Michael D
%A Tabori, Uri
%A Ellison, David W
%A Gilbertson, Richard J
%A Malkin, David
%T Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups.
%J Clinical cancer research
%V 21
%N 1
%@ 1557-3265
%C Philadelphia, Pa. [u.a.]
%I AACR
%M DKFZ-2017-03123
%P 184 - 192
%D 2015
%X To investigate molecular alterations in choroid plexus tumors (CPT) using a genome-wide high-throughput approach to identify diagnostic and prognostic signatures that will refine tumor stratification and guide therapeutic options.One hundred CPTs were obtained from a multi-institutional tissue and clinical database. Copy-number (CN), DNA methylation, and gene expression signatures were assessed for 74, 36, and 40 samples, respectively. Molecular subgroups were correlated with clinical parameters and outcomes.Unique molecular signatures distinguished choroid plexus carcinomas (CPC) from choroid plexus papillomas (CPP) and atypical choroid plexus papillomas (aCPP); however, no significantly distinct molecular alterations between CPPs and aCPPs were observed. Allele-specific CN analysis of CPCs revealed two novel subgroups according to DNA content: hypodiploid and hyperdiploid CPCs. Hyperdiploid CPCs exhibited recurrent acquired uniparental disomy events. Somatic mutations in TP53 were observed in 60
%K Neoplasm Proteins (NLM Chemicals)
%K TP53 protein, human (NLM Chemicals)
%K Tumor Suppressor Protein p53 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25336695
%R 10.1158/1078-0432.CCR-14-1324
%U https://inrepo02.dkfz.de/record/127097