TY  - JOUR
AU  - Merino, Diana M
AU  - Shlien, Adam
AU  - Villani, Anita
AU  - Pienkowska, Malgorzata
AU  - Mack, Stephen
AU  - Ramaswamy, Vijay
AU  - Shih, David
AU  - Tatevossian, Ruth
AU  - Novokmet, Ana
AU  - Choufani, Sanaa
AU  - Dvir, Rina
AU  - Ben-Arush, Myran
AU  - Harris, Brent T
AU  - Hwang, Eugene I
AU  - Lulla, Rishi
AU  - Pfister, Stefan
AU  - Achatz, Maria Isabel
AU  - Jabado, Nada
AU  - Finlay, Jonathan L
AU  - Weksberg, Rosanna
AU  - Bouffet, Eric
AU  - Hawkins, Cynthia
AU  - Taylor, Michael D
AU  - Tabori, Uri
AU  - Ellison, David W
AU  - Gilbertson, Richard J
AU  - Malkin, David
TI  - Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups.
JO  - Clinical cancer research
VL  - 21
IS  - 1
SN  - 1557-3265
CY  - Philadelphia, Pa. [u.a.]
PB  - AACR
M1  - DKFZ-2017-03123
SP  - 184 - 192
PY  - 2015
AB  - To investigate molecular alterations in choroid plexus tumors (CPT) using a genome-wide high-throughput approach to identify diagnostic and prognostic signatures that will refine tumor stratification and guide therapeutic options.One hundred CPTs were obtained from a multi-institutional tissue and clinical database. Copy-number (CN), DNA methylation, and gene expression signatures were assessed for 74, 36, and 40 samples, respectively. Molecular subgroups were correlated with clinical parameters and outcomes.Unique molecular signatures distinguished choroid plexus carcinomas (CPC) from choroid plexus papillomas (CPP) and atypical choroid plexus papillomas (aCPP); however, no significantly distinct molecular alterations between CPPs and aCPPs were observed. Allele-specific CN analysis of CPCs revealed two novel subgroups according to DNA content: hypodiploid and hyperdiploid CPCs. Hyperdiploid CPCs exhibited recurrent acquired uniparental disomy events. Somatic mutations in TP53 were observed in 60
KW  - Neoplasm Proteins (NLM Chemicals)
KW  - TP53 protein, human (NLM Chemicals)
KW  - Tumor Suppressor Protein p53 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25336695
DO  - DOI:10.1158/1078-0432.CCR-14-1324
UR  - https://inrepo02.dkfz.de/record/127097
ER  -