%0 Journal Article
%A Merz, Maximilian
%A Ritsch, Judith
%A Kunz, Christina
%A Wagner, Barbara
%A Sauer, Sandra
%A Hose, Dirk
%A Moehler, Thomas
%A Delorme, Stefan
%A Goldschmidt, Hartmut
%A Zechmann, Christian
%A Hillengass, Jens
%T Dynamic contrast-enhanced magnetic resonance imaging for assessment of antiangiogenic treatment effects in multiple myeloma.
%J Clinical cancer research
%V 21
%N 1
%@ 1557-3265
%C Philadelphia, Pa. [u.a.]
%I AACR
%M DKFZ-2017-03150
%P 106 - 112
%D 2015
%X To noninvasively assess bone marrow microcirculation before and after therapy in patients with newly diagnosed multiple myeloma with dynamic contrast-enhanced MRI (DCE-MRI).Ninety-six patients received DCE-MRI before and after primary treatment for newly diagnosed multiple myeloma. For the 91 evaluable patients, treatment consisted of high-dose therapy (HDT) with autologous stem cell transplantation (ASCT) in 82 patients and chemotherapy without ASCT in 9 patients. In addition, 33 healthy volunteers were imaged as the control group. Analysis of DCE-MRI was performed according to the two-compartment model by Brix to quantify amplitude A (associated with blood volume) and exchange rate constant kep (reflecting vessel permeability and perfusion).Nonresponders showed significantly higher A-values before the start of therapy compared with responders (P = 0.02). In both responders and nonresponders to therapy, A-values dropped significantly (P = 0.004 and <0.001, respectively) after primary therapy, whereas lower values for kep were found only in responders (P < 0.001). Depth of remission was significantly correlated to decreased bone marrow microcirculation: Patients in near complete response (nCR) or complete remission (CR) after treatment showed significantly lower values for A compared with patients not achieving nCR+CR. The application of HDT or novel agents had no significant effect on DCE-MRI parameters after therapy, although patients treated with novel agents more often achieved nCR+CR (42
%K Angiogenesis Inhibitors (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25351744
%R 10.1158/1078-0432.CCR-14-1029
%U https://inrepo02.dkfz.de/record/127124