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| Home > Publications database > Dynamic contrast-enhanced magnetic resonance imaging for assessment of antiangiogenic treatment effects in multiple myeloma. > print |
| 001 | 127124 | ||
| 005 | 20240228140907.0 | ||
| 024 | 7 | _ | |a 10.1158/1078-0432.CCR-14-1029 |2 doi |
| 024 | 7 | _ | |a pmid:25351744 |2 pmid |
| 024 | 7 | _ | |a 1078-0432 |2 ISSN |
| 024 | 7 | _ | |a 1557-3265 |2 ISSN |
| 024 | 7 | _ | |a altmetric:2820486 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-03150 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Merz, Maximilian |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Dynamic contrast-enhanced magnetic resonance imaging for assessment of antiangiogenic treatment effects in multiple myeloma. |
| 260 | _ | _ | |a Philadelphia, Pa. [u.a.] |c 2015 |b AACR |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1522328397_8698 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a To noninvasively assess bone marrow microcirculation before and after therapy in patients with newly diagnosed multiple myeloma with dynamic contrast-enhanced MRI (DCE-MRI).Ninety-six patients received DCE-MRI before and after primary treatment for newly diagnosed multiple myeloma. For the 91 evaluable patients, treatment consisted of high-dose therapy (HDT) with autologous stem cell transplantation (ASCT) in 82 patients and chemotherapy without ASCT in 9 patients. In addition, 33 healthy volunteers were imaged as the control group. Analysis of DCE-MRI was performed according to the two-compartment model by Brix to quantify amplitude A (associated with blood volume) and exchange rate constant kep (reflecting vessel permeability and perfusion).Nonresponders showed significantly higher A-values before the start of therapy compared with responders (P = 0.02). In both responders and nonresponders to therapy, A-values dropped significantly (P = 0.004 and <0.001, respectively) after primary therapy, whereas lower values for kep were found only in responders (P < 0.001). Depth of remission was significantly correlated to decreased bone marrow microcirculation: Patients in near complete response (nCR) or complete remission (CR) after treatment showed significantly lower values for A compared with patients not achieving nCR+CR. The application of HDT or novel agents had no significant effect on DCE-MRI parameters after therapy, although patients treated with novel agents more often achieved nCR+CR (42%/12.5%; P < 0.002). Higher kep-values at second MRI were positively correlated to shorter overall survival (HR 3.53; 95% confidence intervals, 1.21-10.33; P = 0.02).Parameters from DCE-MRI are correlated to remission after primary therapy and outcome in newly diagnosed multiple myeloma. |
| 536 | _ | _ | |a 315 - Imaging and radiooncology (POF3-315) |0 G:(DE-HGF)POF3-315 |c POF3-315 |f POF III |x 0 |
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| 650 | _ | 7 | |a Angiogenesis Inhibitors |2 NLM Chemicals |
| 700 | 1 | _ | |a Ritsch, Judith |b 1 |
| 700 | 1 | _ | |a Kunz, Christina |0 P:(DE-He78)a9f6104e5c2c26345dcb242e6bdcb2b2 |b 2 |u dkfz |
| 700 | 1 | _ | |a Wagner, Barbara |b 3 |
| 700 | 1 | _ | |a Sauer, Sandra |b 4 |
| 700 | 1 | _ | |a Hose, Dirk |b 5 |
| 700 | 1 | _ | |a Moehler, Thomas |b 6 |
| 700 | 1 | _ | |a Delorme, Stefan |0 P:(DE-He78)3e76653311420a51a5faeb80363bd73e |b 7 |u dkfz |
| 700 | 1 | _ | |a Goldschmidt, Hartmut |b 8 |
| 700 | 1 | _ | |a Zechmann, Christian |b 9 |
| 700 | 1 | _ | |a Hillengass, Jens |0 P:(DE-He78)7ccc574e713526d2a22d7acb9b2248c5 |b 10 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1158/1078-0432.CCR-14-1029 |g Vol. 21, no. 1, p. 106 - 112 |0 PERI:(DE-600)2036787-9 |n 1 |p 106 - 112 |t Clinical cancer research |v 21 |y 2015 |x 1557-3265 |
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