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000127149 0247_ $$2doi$$a10.1111/his.12431
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000127149 1001_ $$0P:(DE-HGF)0$$aKoelsche, Christian$$b0$$eFirst author
000127149 245__ $$aNuclear relocation of STAT6 reliably predicts NAB2-STAT6 fusion for the diagnosis of solitary fibrous tumour.
000127149 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2014
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000127149 520__ $$aNuclear relocation of STAT6 has been shown in tumours with NAB2-STAT6 fusion, and has been proposed as an ancillary marker for the diagnosis of solitary fibrous tumours (SFTs). The aim of this study was to verify the utility of STAT6 immunohistology in diagnosing SFT.A total of 689 formalin-fixed paraffin-embedded tumours comprising 35 pleural SFTs and 654 other mesenchymal tumours were investigated for STAT6 expression using immunohistochemistry. Nine dedifferentiated liposarcomas (DDLSs) and five SFTs were also examined for the presence of NAB2-STAT6 fusion at the protein level using the proximity ligation assay (PLA), and for copy number variants (CNVs) with the Illumina Infinium Human Methylation450 array. Thirty-four of 35 SFTs showed strong nuclear STAT6 expression. Furthermore, five of 68 DDLSs, two of 130 undifferentiated pleomorphic sarcomas and one of 63 cases of nodular fasciitis showed moderate to strong nuclear STAT6 expression. The PLA indicated the presence of NAB2-STAT6 fusion protein in SFTs, but signal was also detected in some DDLSs. Copy number analysis showed an overall low frequency of chromosomal imbalances in SFTs, but complex karyotypes in DDLSs, including amplification of STAT6 and MDM2 loci.The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of SFTs, and may serve as a diagnostic marker that indicates NAB2-STAT6 fusion and helps to discriminate SFTs from histological mimics.
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000127149 650_7 $$2NLM Chemicals$$aBiomarkers, Tumor
000127149 650_7 $$2NLM Chemicals$$aNAB2 protein, human
000127149 650_7 $$2NLM Chemicals$$aRepressor Proteins
000127149 650_7 $$2NLM Chemicals$$aSTAT6 Transcription Factor
000127149 650_7 $$2NLM Chemicals$$aSTAT6 protein, human
000127149 7001_ $$0P:(DE-HGF)0$$aSchweizer, Leonille$$b1
000127149 7001_ $$aRenner, Marcus$$b2
000127149 7001_ $$aWarth, Arne$$b3
000127149 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b4$$udkfz
000127149 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b5$$udkfz
000127149 7001_ $$0P:(DE-HGF)0$$aReuss, David E$$b6
000127149 7001_ $$0P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c$$aCapper, David$$b7$$udkfz
000127149 7001_ $$aKnösel, Thomas$$b8
000127149 7001_ $$aSchulz, Birte$$b9
000127149 7001_ $$aPetersen, Iver$$b10
000127149 7001_ $$aUlrich, Alexis$$b11
000127149 7001_ $$aRenker, Eva Kristin$$b12
000127149 7001_ $$aLehner, Burkhard$$b13
000127149 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b14$$udkfz
000127149 7001_ $$aSchirmacher, Peter$$b15
000127149 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b16$$udkfz
000127149 7001_ $$aMechtersheimer, Gunhild$$b17
000127149 773__ $$0PERI:(DE-600)2006447-0$$a10.1111/his.12431$$gVol. 65, no. 5, p. 613 - 622$$n5$$p613 - 622$$tHistopathology$$v65$$x0309-0167$$y2014
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