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@ARTICLE{Mudduluru:127177,
      author       = {G. Mudduluru$^*$ and M. L. Abba$^*$ and J. Batliner$^*$ and
                      N. S. Patil$^*$ and M. Scharp$^*$ and T. R. Lunavat$^*$ and
                      J. H. Leupold$^*$ and O. Oleksiuk$^*$ and D. Juraeva$^*$ and
                      W. Thiele and M. Rothley and A. Benner$^*$ and Y. Ben-Neriah
                      and J. Sleeman and H. Allgayer$^*$},
      title        = {{A} {S}ystematic {A}pproach to {D}efining the micro{RNA}
                      {L}andscape in {M}etastasis.},
      journal      = {Cancer research},
      volume       = {75},
      number       = {15},
      issn         = {1538-7445},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2017-03203},
      pages        = {3010 - 3019},
      year         = {2015},
      abstract     = {The microRNA (miRNA) landscape changes during the
                      progression of cancer. We defined a metastasis-associated
                      miRNA landscape using a systematic approach. We profiled and
                      validated miRNA and mRNA expression in a unique series of
                      human colorectal metastasis tissues together with their
                      matched primary tumors and corresponding normal tissues. We
                      identified an exclusive miRNA signature that is
                      differentially expressed in metastases. Three of these
                      miRNAs were identified as key drivers of an EMT-regulating
                      network acting though a number of novel targets. These
                      targets include SIAH1, SETD2, ZEB2, and especially FOXN3,
                      which we demonstrated for the first time as a direct
                      transcriptional suppressor of N-cadherin. The modulation of
                      N-cadherin expression had significant impact on migration,
                      invasion, and metastasis in two different in vivo models.
                      The significant deregulation of the miRNAs defining the
                      network was confirmed in an independent patient set as well
                      as in a database of diverse malignancies derived from more
                      than 6,000 patients. Our data define a novel
                      metastasis-orchestrating network based on systematic
                      hypothesis generation from metastasis tissues.},
      keywords     = {Antigens, CD (NLM Chemicals) / CDH2 protein, human (NLM
                      Chemicals) / Cadherins (NLM Chemicals) / Cell Cycle Proteins
                      (NLM Chemicals) / FOXN3 protein, human (NLM Chemicals) /
                      Homeodomain Proteins (NLM Chemicals) / MIRN135 microRNA,
                      human (NLM Chemicals) / MIRN210 microRNA, human (NLM
                      Chemicals) / MIRN218 microRNA, human (NLM Chemicals) /
                      MicroRNAs (NLM Chemicals) / Nuclear Proteins (NLM Chemicals)
                      / Repressor Proteins (NLM Chemicals) / ZEB2 protein, human
                      (NLM Chemicals) / Histone-Lysine N-Methyltransferase (NLM
                      Chemicals) / Set2 protein, human (NLM Chemicals) /
                      Ubiquitin-Protein Ligases (NLM Chemicals) / seven in
                      absentia proteins (NLM Chemicals)},
      cin          = {L201 / G360 / C060 / G200},
      ddc          = {610},
      cid          = {I:(DE-He78)L201-20160331 / I:(DE-He78)G360-20160331 /
                      I:(DE-He78)C060-20160331 / I:(DE-He78)G200-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26069251},
      doi          = {10.1158/0008-5472.CAN-15-0997},
      url          = {https://inrepo02.dkfz.de/record/127177},
}