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000127252 0247_ $$2ISSN$$a1538-7755
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000127252 041__ $$aeng
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000127252 1001_ $$0P:(DE-He78)333482b724e4a621465ccc9a939da8dc$$aOse, Jennifer$$b0$$eFirst author$$udkfz
000127252 245__ $$aInflammatory Markers and Risk of Epithelial Ovarian Cancer by Tumor Subtypes: The EPIC Cohort.
000127252 260__ $$aPhiladelphia, Pa.$$bAACR$$c2015
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000127252 520__ $$aEvidence suggests an etiologic role for inflammation in ovarian carcinogenesis and heterogeneity between tumor subtypes and anthropometric indices. Prospective studies on circulating inflammatory markers and epithelial invasive ovarian cancer (EOC) have predominantly investigated overall risk; data characterizing risk by tumor characteristics (histology, grade, stage, dualistic model of ovarian carcinogenesis) and anthropometric indices are sparse.We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate C-reactive protein (CRP), IL6, and EOC risk by tumor characteristics. A total of 754 eligible EOC cases were identified; two controls (n = 1,497) were matched per case. We used multivariable conditional logistic regression to assess associations.CRP and IL6 were not associated with overall EOC risk. However, consistent with prior research, CRP >10 versus CRP ≤1 mg/L was associated with higher overall EOC risk [OR, 1.67 (1.03-2.70)]. We did not observe significant associations or heterogeneity in analyses by tumor characteristics. In analyses stratified by waist circumference, inflammatory markers were associated with higher risk among women with higher waist circumference; no association was observed for women with normal waist circumference [e.g., IL6: waist ≤80: ORlog2, 0.97 (0.81-1.16); waist >88: ORlog2, 1.78 (1.28-2.48), Pheterogeneity ≤ 0.01].Our data suggest that high CRP is associated with increased risk of overall EOC, and that IL6 and CRP may be associated with EOC risk among women with higher adiposity.Our data add to global evidence that ovarian carcinogenesis may be promoted by an inflammatory milieu.
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000127252 650_7 $$2NLM Chemicals$$aBiomarkers, Tumor
000127252 650_7 $$2NLM Chemicals$$aInflammation Mediators
000127252 7001_ $$0P:(DE-He78)1bd6298f721e4a01f21c2329276a53a7$$aSchock, Helena$$b1$$udkfz
000127252 7001_ $$aTjønneland, Anne$$b2
000127252 7001_ $$aHansen, Louise$$b3
000127252 7001_ $$aOvervad, Kim$$b4
000127252 7001_ $$aDossus, Laure$$b5
000127252 7001_ $$aClavel-Chapelon, Françoise$$b6
000127252 7001_ $$aBaglietto, Laura$$b7
000127252 7001_ $$aBoeing, Heiner$$b8
000127252 7001_ $$aTrichopolou, Antonia$$b9
000127252 7001_ $$aBenetou, Vassiliki$$b10
000127252 7001_ $$aLagiou, Pagona$$b11
000127252 7001_ $$aMasala, Giovanna$$b12
000127252 7001_ $$aTagliabue, Giovanna$$b13
000127252 7001_ $$aTumino, Rosario$$b14
000127252 7001_ $$aSacerdote, Carlotta$$b15
000127252 7001_ $$aMattiello, Amalia$$b16
000127252 7001_ $$aBueno-de-Mesquita, H B As$$b17
000127252 7001_ $$aPeeters, Petra H M$$b18
000127252 7001_ $$aOnland-Moret, N Charlotte$$b19
000127252 7001_ $$aWeiderpass, Elisabete$$b20
000127252 7001_ $$aGram, Inger T$$b21
000127252 7001_ $$aSánchez, Soledad$$b22
000127252 7001_ $$aObon-Santacana, Mireia$$b23
000127252 7001_ $$aSànchez-Pérez, Maria-José$$b24
000127252 7001_ $$aLarrañaga, Nerea$$b25
000127252 7001_ $$aCastaño, José María Huerta$$b26
000127252 7001_ $$aArdanaz, Eva$$b27
000127252 7001_ $$aBrändstedt, Jenny$$b28
000127252 7001_ $$aLundin, Eva$$b29
000127252 7001_ $$aIdahl, Annika$$b30
000127252 7001_ $$aTravis, Ruth C$$b31
000127252 7001_ $$aKhaw, Kay-Tee$$b32
000127252 7001_ $$aRinaldi, Sabina$$b33
000127252 7001_ $$aRomieu, Isabelle$$b34
000127252 7001_ $$aMerritt, Melissa A$$b35
000127252 7001_ $$aGunter, Marc J$$b36
000127252 7001_ $$aRiboli, Elio$$b37
000127252 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b38$$udkfz
000127252 7001_ $$0P:(DE-He78)74a6af8347ec5cbd4b77e562e10ca1f2$$aTurzanski-Fortner, Renée$$b39$$eLast author$$udkfz
000127252 773__ $$0PERI:(DE-600)2036781-8$$a10.1158/1055-9965.EPI-14-1279-T$$gVol. 24, no. 6, p. 951 - 961$$n6$$p951 - 961$$tCancer epidemiology, biomarkers & prevention$$v24$$x1538-7755$$y2015
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