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@ARTICLE{Ose:127252,
      author       = {J. Ose$^*$ and H. Schock$^*$ and A. Tjønneland and L.
                      Hansen and K. Overvad and L. Dossus and F. Clavel-Chapelon
                      and L. Baglietto and H. Boeing and A. Trichopolou and V.
                      Benetou and P. Lagiou and G. Masala and G. Tagliabue and R.
                      Tumino and C. Sacerdote and A. Mattiello and H. B. A.
                      Bueno-de-Mesquita and P. H. M. Peeters and N. C.
                      Onland-Moret and E. Weiderpass and I. T. Gram and S.
                      Sánchez and M. Obon-Santacana and M.-J. Sànchez-Pérez and
                      N. Larrañaga and J. M. H. Castaño and E. Ardanaz and J.
                      Brändstedt and E. Lundin and A. Idahl and R. C. Travis and
                      K.-T. Khaw and S. Rinaldi and I. Romieu and M. A. Merritt
                      and M. J. Gunter and E. Riboli and R. Kaaks$^*$ and R.
                      Turzanski-Fortner$^*$},
      title        = {{I}nflammatory {M}arkers and {R}isk of {E}pithelial
                      {O}varian {C}ancer by {T}umor {S}ubtypes: {T}he {EPIC}
                      {C}ohort.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {24},
      number       = {6},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2017-03277},
      pages        = {951 - 961},
      year         = {2015},
      abstract     = {Evidence suggests an etiologic role for inflammation in
                      ovarian carcinogenesis and heterogeneity between tumor
                      subtypes and anthropometric indices. Prospective studies on
                      circulating inflammatory markers and epithelial invasive
                      ovarian cancer (EOC) have predominantly investigated overall
                      risk; data characterizing risk by tumor characteristics
                      (histology, grade, stage, dualistic model of ovarian
                      carcinogenesis) and anthropometric indices are sparse.We
                      conducted a nested case-control study in the European
                      Prospective Investigation into Cancer and Nutrition (EPIC)
                      cohort to evaluate C-reactive protein (CRP), IL6, and EOC
                      risk by tumor characteristics. A total of 754 eligible EOC
                      cases were identified; two controls (n = 1,497) were matched
                      per case. We used multivariable conditional logistic
                      regression to assess associations.CRP and IL6 were not
                      associated with overall EOC risk. However, consistent with
                      prior research, CRP >10 versus CRP ≤1 mg/L was associated
                      with higher overall EOC risk [OR, 1.67 (1.03-2.70)]. We did
                      not observe significant associations or heterogeneity in
                      analyses by tumor characteristics. In analyses stratified by
                      waist circumference, inflammatory markers were associated
                      with higher risk among women with higher waist
                      circumference; no association was observed for women with
                      normal waist circumference [e.g., IL6: waist ≤80: ORlog2,
                      0.97 (0.81-1.16); waist >88: ORlog2, 1.78 (1.28-2.48),
                      Pheterogeneity ≤ 0.01].Our data suggest that high CRP is
                      associated with increased risk of overall EOC, and that IL6
                      and CRP may be associated with EOC risk among women with
                      higher adiposity.Our data add to global evidence that
                      ovarian carcinogenesis may be promoted by an inflammatory
                      milieu.},
      keywords     = {Biomarkers, Tumor (NLM Chemicals) / Inflammation Mediators
                      (NLM Chemicals)},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25855626},
      pmc          = {pmc:PMC4454588},
      doi          = {10.1158/1055-9965.EPI-14-1279-T},
      url          = {https://inrepo02.dkfz.de/record/127252},
}