TY  - JOUR
AU  - Owsijewitsch, Michael
AU  - Ley-Zaporozhan, Julia
AU  - Kuhnigk, Jan-Martin
AU  - Kopp-Schneider, Annette
AU  - Eberhardt, Ralf
AU  - Eichinger, Monika
AU  - Heussel, Claus Peter
AU  - Kauczor, Hans-Ulrich
AU  - Ley, Sebastian
TI  - Quantitative Emphysema Distribution in Anatomic and Non-anatomic Lung Regions.
JO  - COPD
VL  - 12
IS  - 3
SN  - 1541-2563
CY  - London
PB  - Taylor & Francis
M1  - DKFZ-2017-03283
SP  - 260 - 270
PY  - 2015
AB  - The change of emphysema distribution with increasing COPD severity is not yet assessed. Especially, involvement of the upper aspect of the lower lobe is unknown. The primary aim was to quantitatively determine regional distribution of emphysema in anatomically (lung lobes) and non-anatomically defined lung regions (upper/lower lung halves as well as core and rind regions) in a cohort covering equally all COPD severity stages using CT.Basically 100 CT data sets were quantitatively evaluated for regional distribution of emphysema. Emphysema characteristics (emphysema index, mean lung density and 15th percentile of the attenuation values of lung voxels) were compared (t-test) in: upper lobes vs. upper halves, lower lobes vs. lower halves, core vs. rind region.In patients with ≤ GOLD II, a significantly higher emphysema burden was found in the upper lobes as compared to upper halves. In subjects with GOLD III/IV the differences were not significant for all emphysema characteristics. A high difference between lobes and halves in subjects with ≤ GOLD II was found, in contrast to low difference in higher GOLD stages.Lobar segmentation provides improved characterization of cranio-caudal emphysema distribution compared to a non-anatomic approach in subjects up to GOLD stage II.
LB  - PUB:(DE-HGF)16
C6  - pmid:25230093
DO  - DOI:10.3109/15412555.2014.933950
UR  - https://inrepo02.dkfz.de/record/127258
ER  -