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@ARTICLE{Owsijewitsch:127258,
      author       = {M. Owsijewitsch and J. Ley-Zaporozhan and J.-M. Kuhnigk and
                      A. Kopp-Schneider$^*$ and R. Eberhardt and M. Eichinger and
                      C. P. Heussel and H.-U. Kauczor and S. Ley},
      title        = {{Q}uantitative {E}mphysema {D}istribution in {A}natomic and
                      {N}on-anatomic {L}ung {R}egions.},
      journal      = {COPD},
      volume       = {12},
      number       = {3},
      issn         = {1541-2563},
      address      = {London},
      publisher    = {Taylor $\&$ Francis},
      reportid     = {DKFZ-2017-03283},
      pages        = {260 - 270},
      year         = {2015},
      abstract     = {The change of emphysema distribution with increasing COPD
                      severity is not yet assessed. Especially, involvement of the
                      upper aspect of the lower lobe is unknown. The primary aim
                      was to quantitatively determine regional distribution of
                      emphysema in anatomically (lung lobes) and non-anatomically
                      defined lung regions (upper/lower lung halves as well as
                      core and rind regions) in a cohort covering equally all COPD
                      severity stages using CT.Basically 100 CT data sets were
                      quantitatively evaluated for regional distribution of
                      emphysema. Emphysema characteristics (emphysema index, mean
                      lung density and 15th percentile of the attenuation values
                      of lung voxels) were compared (t-test) in: upper lobes vs.
                      upper halves, lower lobes vs. lower halves, core vs. rind
                      region.In patients with ≤ GOLD II, a significantly higher
                      emphysema burden was found in the upper lobes as compared to
                      upper halves. In subjects with GOLD III/IV the differences
                      were not significant for all emphysema characteristics. A
                      high difference between lobes and halves in subjects with
                      ≤ GOLD II was found, in contrast to low difference in
                      higher GOLD stages.Lobar segmentation provides improved
                      characterization of cranio-caudal emphysema distribution
                      compared to a non-anatomic approach in subjects up to GOLD
                      stage II.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25230093},
      doi          = {10.3109/15412555.2014.933950},
      url          = {https://inrepo02.dkfz.de/record/127258},
}